Nitrogen analogues of haematoporphyrin and haematoporphyrin derivative.
Affiliation
Department of Chemistry and Chemical Engineering, University of Paisley, Renfrewshire, Scotland, UK.Issue Date
1992-12-24
Metadata
Show full item recordAbstract
The preparation of a number of amines related to haematoporphyrin (HP) and haematoporphyrin derivative (HPD) have been studied and their composition and structure discussed through examination of their 1H, 13C NMR and mass spectral data and other physical properties. In vitro biological studies have been carried out and have shown these amines to have a similar photodynamic efficiency to that of HPD. One of these showed cytotoxic properties at exceptionally low light energy levels.Citation
Nitrogen analogues of haematoporphyrin and haematoporphyrin derivative. 1992, 67 (2-3):175-85 Cancer Lett.Journal
Cancer LettersDOI
10.1016/0304-3835(92)90141-HPubMed ID
1483265Type
ArticleLanguage
enISSN
0304-3835ae974a485f413a2113503eed53cd6c53
10.1016/0304-3835(92)90141-H
Scopus Count
Collections
Related items
Showing items related by title, author, creator and subject.
-
Aggregation effects on the photophysical properties of porphyrins in relation to mechanisms involved in photodynamic therapy.Redmond, R; Land, Edward J; Truscott, T G; Paterson Laboratories, The Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK. (1985)
-
Mechanisms behind the resistance of spheroids to photodynamic treatment: a flow cytometry study.West, Catharine M L; Moore, James V; Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K. (1992-03)The influence of cell heterogeneity on response to photodynamic treatment (PDT) has been investigated using the human colon adenocarcinoma line WiDr, grown as spheroids and exposed to hematoporphyrin derivative. The spheroids show a marked spheroid size-dependent resistance to PDT. Using a flow cytometer, cell sub-populations have been separated, on the basis of drug fluorescence, from single cell suspensions prepared from 500 microm diameter spheroids. Cells low in fluorescence have been shown to be resistant to PDT, have a smaller median cell volume, and be enhanced in G1-type cells. These cells also show reduced low density lipoprotein uptake. The results suggest that spheroid size-dependent resistance to PDT is related to a decreasing growth fraction with increasing spheroid size. Heterogeneity of drug uptake could be a potential limitation to clinical PDT.
-
Low-density lipoprotein uptake and the sensitivity to photodynamic treatment of cultured endothelial cells.West, Catharine M L; West, David C; Moore, James V; Cancer Research Campaign Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, UK. (1991)