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    A study of spindle cell sarcomas showing myofibroblastic differentiation.

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    Authors
    Eyden, Brian P
    Banerjee, Saumitra S
    Harris, Martin
    Mene, A
    Affiliation
    Histopathology Department, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.
    Issue Date
    1991
    
    Metadata
    Show full item record
    Abstract
    Five diagnostically problematic spindle cell sarcomas showing invasive character, cellular pleomorphism, and high mitotic rate were studied clinically and histopathologically by conventional light microscopy, immunohistochemistry, and transmission electron microscopy. They showed varied clinical courses, with two causing death within 5 years and three showing recurrent and metastatic behavior. All lacked a clearly defined line of differentiation by conventional light microscopy. By immunohistochemistry, all were positive for vimentin and alpha-smooth muscle actin; in addition, one showed focal S-100 protein positivity, and one stained for desmin. All were cytokeratin negative. By electron microscopy, the great majority of spindle cells in all cases showed abundant rough endoplasmic reticulum and fine myofilaments with focal densities; collagen secretion granules were also found in all cases but in fewer cells. The fine structure and immunophenotype were considered consistent with myofibroblastic differentiation; these tumors, therefore, were designated as sarcomas of myofibroblasts or myofibrosarcomas. The suitability of the alternative diagnostic label of myofibroblastic or matrix-secreting variant of leiomyosarcoma is discussed. Comparisons with similar tumors documented in the literature are drawn.
    Citation
    A study of spindle cell sarcomas showing myofibroblastic differentiation. 15 (4-5):367-78 Ultrastruct Pathol
    Journal
    Ultrastructural Pathology
    URI
    http://hdl.handle.net/10541/108816
    DOI
    10.3109/01913129109016246
    PubMed ID
    1755101
    Type
    Article
    Language
    en
    ISSN
    0191-3123
    ae974a485f413a2113503eed53cd6c53
    10.3109/01913129109016246
    Scopus Count
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