• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Thyroid function after treatment of brain tumors in children.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Ogilvy-Stuart, Amanda L
    Shalet, Stephen M
    Gattamaneni, Rao
    Affiliation
    Department of Endocrinology, Christie Hospital, Manchester, England.
    Issue Date
    1991-11
    
    Metadata
    Show full item record
    Abstract
    In 134 children who had been treated for a brain tumor not involving the hypothalamic-pituitary axis, thyroid function was assessed up to 24 years after treatment with cranial or craniospinal irradiation. In addition, 78 children received up to 2 years of cytotoxic chemotherapy. Of 85 children who received craniospinal irradiation, 30 (35%) had abnormalities of thyroid function, and 10 (20%) of 49 who received cranial irradiation had such abnormalities. Frank hypothyroidism developed in three children and thyrotoxicosis in one. Thirty-six children had an elevated thyroid-stimulating hormone level in the presence of a normal thyroxine level; in 16 of them the thyroid-stimulating hormone level subsequently returned to normal. Twenty-eight children who were treated between 1960 and 1970 were excluded from the analysis. Of 34 children who received cranial irradiation, five had thyroid dysfunction and 24 of 72 who received craniospinal irradiation had such dysfunction (p = 0.013). Thyroid dysfunction was present in 4 of 35 children who received no chemotherapy and in 25 of 71 who received chemotherapy (p = 0.014). Direct irradiation plus chemotherapy was more damaging than irradiation alone. These data confirm the high incidence of thyroid dysfunction when the thyroid gland is included in the radiation field. However, in a high proportion, the thyroid abnormalities are minor and revert to normal with time; life-long replacement therapy with thyroxine may be unnecessary.
    Citation
    Thyroid function after treatment of brain tumors in children. 1991, 119 (5):733-7 J. Pediatr.
    Journal
    The Journal of Pediatrics
    URI
    http://hdl.handle.net/10541/108815
    DOI
    10.1016/S0022-3476(05)80288-4
    PubMed ID
    1941379
    Type
    Article
    Language
    en
    ISSN
    0022-3476
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0022-3476(05)80288-4
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Thyroid dysfunction after radiotherapy and chemotherapy of brain tumours.
    • Authors: Livesey EA, Brook CG
    • Issue date: 1989 Apr
    • Phase II study of 6-thioguanine, procarbazine, dibromodulcitol, lomustine, and vincristine chemotherapy with radiotherapy for treating malignant glioma in children.
    • Authors: Levin VA, Lamborn K, Wara W, Davis R, Edwards M, Rabbitt J, Malec M, Prados MD
    • Issue date: 2000 Jan
    • Hyperprolactinemia and hypothyroidism following cytotoxic therapy for central nervous system malignancies.
    • Authors: Constine LS, Rubin P, Woolf PD, Doane K, Lush CM
    • Issue date: 1987 Nov
    • A population-based study of thyroid function after radiotherapy and chemotherapy for a childhood brain tumor.
    • Authors: Schmiegelow M, Feldt-Rasmussen U, Rasmussen AK, Poulsen HS, Müller J
    • Issue date: 2003 Jan
    • Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy.
    • Authors: Ricardi U, Corrias A, Einaudi S, Genitori L, Sandri A, di Montezemolo LC, Besenzon L, Madon E, Urgesi A
    • Issue date: 2001 Aug 1
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.