Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation.
| dc.contributor.author | Eyden, Brian P | |
| dc.contributor.author | Dardick, I | |
| dc.contributor.author | Bishop, Paul | |
| dc.date.accessioned | 2010-08-02T12:22:04Z | |
| dc.date.available | 2010-08-02T12:22:04Z | |
| dc.date.issued | 1991 | |
| dc.identifier.citation | Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation. 15 (6):663-70 Ultrastruct Pathol | en |
| dc.identifier.issn | 0191-3123 | |
| dc.identifier.pmid | 1665929 | |
| dc.identifier.doi | 10.3109/01913129109023196 | |
| dc.identifier.uri | http://hdl.handle.net/10541/108808 | |
| dc.description.abstract | A hyaline/eosinophilic cytoplasmic inclusion is described in a metastatic tumor occurring in the omentum and bowel of a 32-year-old white woman. The tumor was essentially of round cell type; was positive for cytokeratin, actin, and S-100 protein by immunohistochemistry; and showed desmosomes (maculae adherentes), tonofibrils, modestly developed myofilaments with focal densities, and a basal lamina by electron microscopy. It was therefore interpreted as showing myoepithelial differentiation. Nearly all cells possessed a large, rounded cytoplasmic inclusion that was architecturally unusual, consisting of intermediate filaments intermingled with lattices of fine filaments. The inclusions exhibited an additionally unusual immunohistochemical staining for both cytokeratin and actin. A comparison with cases described in the literature is made. | |
| dc.language.iso | en | en |
| dc.subject | Intestinal Cancer | en |
| dc.subject | Cancer Metastasis | en |
| dc.subject.mesh | Adult | |
| dc.subject.mesh | Carcinoma | |
| dc.subject.mesh | Cell Differentiation | |
| dc.subject.mesh | Female | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Inclusion Bodies | |
| dc.subject.mesh | Intestinal Neoplasms | |
| dc.subject.mesh | Neoplasm Metastasis | |
| dc.subject.mesh | Treatment Outcome | |
| dc.title | Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation. | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Histopathology, Christie Hospital, Manchester, United Kingdom. | en |
| dc.identifier.journal | Ultrastructural Pathology | en |
| html.description.abstract | A hyaline/eosinophilic cytoplasmic inclusion is described in a metastatic tumor occurring in the omentum and bowel of a 32-year-old white woman. The tumor was essentially of round cell type; was positive for cytokeratin, actin, and S-100 protein by immunohistochemistry; and showed desmosomes (maculae adherentes), tonofibrils, modestly developed myofilaments with focal densities, and a basal lamina by electron microscopy. It was therefore interpreted as showing myoepithelial differentiation. Nearly all cells possessed a large, rounded cytoplasmic inclusion that was architecturally unusual, consisting of intermediate filaments intermingled with lattices of fine filaments. The inclusions exhibited an additionally unusual immunohistochemical staining for both cytokeratin and actin. A comparison with cases described in the literature is made. |