Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation.
Affiliation
Department of Histopathology, Christie Hospital, Manchester, United Kingdom.Issue Date
1991
Metadata
Show full item recordAbstract
A hyaline/eosinophilic cytoplasmic inclusion is described in a metastatic tumor occurring in the omentum and bowel of a 32-year-old white woman. The tumor was essentially of round cell type; was positive for cytokeratin, actin, and S-100 protein by immunohistochemistry; and showed desmosomes (maculae adherentes), tonofibrils, modestly developed myofilaments with focal densities, and a basal lamina by electron microscopy. It was therefore interpreted as showing myoepithelial differentiation. Nearly all cells possessed a large, rounded cytoplasmic inclusion that was architecturally unusual, consisting of intermediate filaments intermingled with lattices of fine filaments. The inclusions exhibited an additionally unusual immunohistochemical staining for both cytokeratin and actin. A comparison with cases described in the literature is made.Citation
Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation. 15 (6):663-70 Ultrastruct PatholJournal
Ultrastructural PathologyDOI
10.3109/01913129109023196PubMed ID
1665929Type
ArticleLanguage
enISSN
0191-3123ae974a485f413a2113503eed53cd6c53
10.3109/01913129109023196
Scopus Count
Collections
Related articles
- Basal cell carcinoma with hyaline inclusions.
- Authors: Sahin AA, Ro JY, Grignon DJ, Ordóñez NG
- Issue date: 1989 Sep
- Desmin and actin associated with cytoplasmic bodies in skeletal muscle fibers: immunocytochemical and fine structural studies, with a note on unusual 18- to 20-nm filaments.
- Authors: Schröder JM, Sommer C, Schmidt B
- Issue date: 1990
- Pleomorphic carcinoma of the small bowel. The limitations of immunohistochemical specificity.
- Authors: Jones EA, Flejou JF, Molas G, Potet F
- Issue date: 1991 Mar
- Novel eosinophilic intracytoplasmic inclusions in a meningioma.
- Authors: Kawasaki K, Takahashi H, Kaneko H, Sato H, Ikuta F
- Issue date: 1993 Nov 1
- Basal cell carcinoma with myoepithelial differentiation: a distinct plasmacytoid cell variant with hyaline inclusions.
- Authors: Na SY, Choi YD, Choi C, Kim SJ, Won YH, Yun SJ
- Issue date: 2011 May