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dc.contributor.authorBishop, P W
dc.contributor.authorHarris, Martin
dc.contributor.authorSmith, A P
dc.contributor.authorElsam, K J
dc.date.accessioned2010-08-02T10:21:31Z
dc.date.available2010-08-02T10:21:31Z
dc.date.issued1991-01
dc.identifier.citationImmunophenotypic study of lymphocyte predominance Hodgkin's disease. 1991, 18 (1):19-24 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid2013458
dc.identifier.doi10.1111/j.1365-2559.1991.tb00809.x
dc.identifier.urihttp://hdl.handle.net/10541/108801
dc.description.abstractAn immunophenotypic study of 17 cases of diffuse lymphocyte predominance Hodgkin's disease and 20 cases of nodular lymphocyte predominance Hodgkin's disease, along with eight of mixed cellularity and five of nodular sclerosing Hodgkin's disease, is reported. The atypical cells in nodular lymphocyte predominance Hodgkin's disease showed only minor differences from the published consensus. However, the atypical cells in diffuse lymphocyte predominance Hodgkin's disease showed an immunophenotype which was commonly B-cell positive (59%), but in a minority of cases LeuM1 (24%) or epithelial membrane antigen (12%) positive; none of the cases was Ber-H2 positive. These results do not differ greatly from our findings in nodular lymphocyte predominance Hodgkin's disease, but do diverge from the published consensus for diffuse lymphocyte predominance Hodgkin's disease. The question as to whether morphology or immunophenotype should form the primary diagnostic criterion for the definition of lymphocyte predominance Hodgkin's disease is discussed.
dc.language.isoenen
dc.subject.meshAntigens, Differentiation, Myelomonocytic
dc.subject.meshHodgkin Disease
dc.subject.meshHumans
dc.subject.meshImmunophenotyping
dc.subject.meshLymphocytes
dc.subject.meshMembrane Glycoproteins
dc.subject.meshMucin-1
dc.titleImmunophenotypic study of lymphocyte predominance Hodgkin's disease.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Christie Hospital, Manchester, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractAn immunophenotypic study of 17 cases of diffuse lymphocyte predominance Hodgkin's disease and 20 cases of nodular lymphocyte predominance Hodgkin's disease, along with eight of mixed cellularity and five of nodular sclerosing Hodgkin's disease, is reported. The atypical cells in nodular lymphocyte predominance Hodgkin's disease showed only minor differences from the published consensus. However, the atypical cells in diffuse lymphocyte predominance Hodgkin's disease showed an immunophenotype which was commonly B-cell positive (59%), but in a minority of cases LeuM1 (24%) or epithelial membrane antigen (12%) positive; none of the cases was Ber-H2 positive. These results do not differ greatly from our findings in nodular lymphocyte predominance Hodgkin's disease, but do diverge from the published consensus for diffuse lymphocyte predominance Hodgkin's disease. The question as to whether morphology or immunophenotype should form the primary diagnostic criterion for the definition of lymphocyte predominance Hodgkin's disease is discussed.


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