AffiliationCarcinogenesis Department, Christie Hospital and Holt Radium Institute, Manchester, Great Britain.
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AbstractFecapentaenes are a class of conjugated ether lipids which have been identified as the major component of human fecal mutagenicity in the Ames Salmonella mutagenesis assay. Human epidemiologic data have indicated that most healthy North American populations eating a western diet do excrete detectable levels of fecapentaenes. Excreted fecapentaene levels seem to reflect levels throughout the colonic lumen, and levels vary characteristically between individuals. Those individuals found to excrete high levels of fecapentaene appear, based on limited data, to be at decreased risk of colorectal neoplasia. Carcinogenicity studies in rats and mice have been predominantly negative, however, increased tumor incidence in mice exposed to fecapentaenes as neonates has recently been reported. Fecapentaenes are direct-acting genotoxins, which may react with DNA through free radical mechanisms, and/or aldehyde formation. Mechanisms by which fecapentaene-induced DNA damage may mediate carcinogenesis are discussed.
CitationLaboratory and epidemiologic studies of fecapentaenes.259 (3-4):387-97 Mutat Res.
- Fecapentaene excretion and fecal mutagenicity in relation to nutrient intake and fecal parameters in humans on omnivorous and vegetarian diets.
- Authors: de Kok TM, van Faassen A, Bausch-Goldbohm RA, ten Hoor F, Kleinjans JC
- Issue date: 1992 Feb 14
- Fecapentaene concentration and mutagenicity in 718 North American stool samples.
- Authors: Schiffman MH, Van Tassell RL, Andrews AW, Wacholder S, Daniel J, Robinson A, Smith L, Nair PP, Wilkins TD
- Issue date: 1989 Apr
- Relation of changes in amount and type of dietary fat to fecapentaenes in premenopausal women.
- Authors: Taylor PR, Schiffman MH, Jones DY, Judd J, Schatzkin A, Nair PP, Van Tassell R, Block G
- Issue date: 1988 Sep
- Identification and quantitative distribution of eight analogues of naturally occurring fecapentaenes in human feces by high-performance liquid chromatography.
- Authors: de Kok TM, ten Hoor F, Kleinjans JC
- Issue date: 1991 Feb
- Genotoxic mechanisms of fecapentaene-12 in human cells.
- Authors: Povey AC, Plummer SM, Grafstrom RC, Harris CC
- Issue date: 1990