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    Laboratory and epidemiologic studies of fecapentaenes.

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    Authors
    Povey, Andrew C
    Schiffman, M
    Taffe, B G
    Harris, C C
    Affiliation
    Carcinogenesis Department, Christie Hospital and Holt Radium Institute, Manchester, Great Britain.
    Issue Date
    1991
    
    Metadata
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    Abstract
    Fecapentaenes are a class of conjugated ether lipids which have been identified as the major component of human fecal mutagenicity in the Ames Salmonella mutagenesis assay. Human epidemiologic data have indicated that most healthy North American populations eating a western diet do excrete detectable levels of fecapentaenes. Excreted fecapentaene levels seem to reflect levels throughout the colonic lumen, and levels vary characteristically between individuals. Those individuals found to excrete high levels of fecapentaene appear, based on limited data, to be at decreased risk of colorectal neoplasia. Carcinogenicity studies in rats and mice have been predominantly negative, however, increased tumor incidence in mice exposed to fecapentaenes as neonates has recently been reported. Fecapentaenes are direct-acting genotoxins, which may react with DNA through free radical mechanisms, and/or aldehyde formation. Mechanisms by which fecapentaene-induced DNA damage may mediate carcinogenesis are discussed.
    Citation
    Laboratory and epidemiologic studies of fecapentaenes.259 (3-4):387-97 Mutat Res.
    Journal
    Mutation Research
    URI
    http://hdl.handle.net/10541/108787
    PubMed ID
    2017218
    Type
    Article
    Language
    en
    ISSN
    0027-5107
    Collections
    All Christie Publications

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