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dc.contributor.authorJames, Roger D
dc.contributor.authorHaboubi, Najib
dc.contributor.authorSchofield, Philip F
dc.contributor.authorMellor, M
dc.contributor.authorSalhab, N
dc.date.accessioned2010-08-02T09:35:40Z
dc.date.available2010-08-02T09:35:40Z
dc.date.issued1991-07
dc.identifier.citationPrognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery. 1991, 34 (7):546-51 Dis. Colon Rectumen
dc.identifier.issn0012-3706
dc.identifier.pmid2055140
dc.identifier.doi10.1007/BF02049892
dc.identifier.urihttp://hdl.handle.net/10541/108778
dc.description.abstractThe clinicopathologic staging of colorectal cancer is the subject of recent debate. We studied morphologic variables in a series of tumors resected from 284 patients. Half had been prospectively, randomly allocated to receive a 4-day schedule of preoperative pelvic radiotherapy followed by immediate surgery. There was a significant (P less than 0.01) difference in the distribution of tumors of various histopathologic grades between irradiated (XS) and unirradiated (S) patients and borderline differences in the predictive values of venous spread, tumor grading, and local spread. However, these differences were less marked in 180 tumors examined by one review pathologist. They were thought to be due to misinterpretation of changes induced by radiotherapy. No differences were detected in the distribution of tumors of various sizes and Dukes' stage in the XS and S groups. The review pathologist recorded a borderline (P = 0.049) difference in the distribution of tumors of various CEA staining patterns between the XS and S groups. In a Cox regression model. Dukes' staging remained the most important predictive variable for survival and pelvic recurrence in the XS and S groups. Dukes' staging was apparently unchanged by this schedule of preoperative radiotherapy, but Broders' grading may be unreliable. Any new clinicopathologic staging system for colorectal cancer should record when preoperative radiotherapy is delivered. More studies of radiotherapy effects are required.
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subjectCancer Invasivenessen
dc.subjectCancer Stagingen
dc.subject.meshAdenocarcinoma
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCarcinoembryonic Antigen
dc.subject.meshColorectal Neoplasms
dc.subject.meshCombined Modality Therapy
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Invasiveness
dc.subject.meshNeoplasm Staging
dc.subject.meshPrognosis
dc.subject.meshRegression Analysis
dc.subject.meshSurvival Rate
dc.titlePrognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiotherapy, Christie Hospital, Withington, Manchester, United Kingdom.en
dc.identifier.journalDiseases of the Colon and Rectumen
html.description.abstractThe clinicopathologic staging of colorectal cancer is the subject of recent debate. We studied morphologic variables in a series of tumors resected from 284 patients. Half had been prospectively, randomly allocated to receive a 4-day schedule of preoperative pelvic radiotherapy followed by immediate surgery. There was a significant (P less than 0.01) difference in the distribution of tumors of various histopathologic grades between irradiated (XS) and unirradiated (S) patients and borderline differences in the predictive values of venous spread, tumor grading, and local spread. However, these differences were less marked in 180 tumors examined by one review pathologist. They were thought to be due to misinterpretation of changes induced by radiotherapy. No differences were detected in the distribution of tumors of various sizes and Dukes' stage in the XS and S groups. The review pathologist recorded a borderline (P = 0.049) difference in the distribution of tumors of various CEA staining patterns between the XS and S groups. In a Cox regression model. Dukes' staging remained the most important predictive variable for survival and pelvic recurrence in the XS and S groups. Dukes' staging was apparently unchanged by this schedule of preoperative radiotherapy, but Broders' grading may be unreliable. Any new clinicopathologic staging system for colorectal cancer should record when preoperative radiotherapy is delivered. More studies of radiotherapy effects are required.


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