Prognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery.
AffiliationDepartment of Radiotherapy, Christie Hospital, Withington, Manchester, United Kingdom.
MetadataShow full item record
AbstractThe clinicopathologic staging of colorectal cancer is the subject of recent debate. We studied morphologic variables in a series of tumors resected from 284 patients. Half had been prospectively, randomly allocated to receive a 4-day schedule of preoperative pelvic radiotherapy followed by immediate surgery. There was a significant (P less than 0.01) difference in the distribution of tumors of various histopathologic grades between irradiated (XS) and unirradiated (S) patients and borderline differences in the predictive values of venous spread, tumor grading, and local spread. However, these differences were less marked in 180 tumors examined by one review pathologist. They were thought to be due to misinterpretation of changes induced by radiotherapy. No differences were detected in the distribution of tumors of various sizes and Dukes' stage in the XS and S groups. The review pathologist recorded a borderline (P = 0.049) difference in the distribution of tumors of various CEA staining patterns between the XS and S groups. In a Cox regression model. Dukes' staging remained the most important predictive variable for survival and pelvic recurrence in the XS and S groups. Dukes' staging was apparently unchanged by this schedule of preoperative radiotherapy, but Broders' grading may be unreliable. Any new clinicopathologic staging system for colorectal cancer should record when preoperative radiotherapy is delivered. More studies of radiotherapy effects are required.
CitationPrognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery. 1991, 34 (7):546-51 Dis. Colon Rectum
JournalDiseases of the Colon and Rectum
- Multivariate analysis of the prognostic value of CEA and CA 19-9 serum levels in colorectal cancer.
- Authors: Reiter W, Stieber P, Reuter C, Nagel D, Lau-Werner U, Lamerz R
- Issue date: 2000 Nov-Dec
- Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer.
- Authors: Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Matsuda K, Fukushima R, Okinaga K, Sasako M, Mori M
- Issue date: 2011 Apr 20
- Prognostic significance of CEA and CA 19-9 in colorectal cancer in Kuwait.
- Authors: Behbehani AI, Al-Sayer H, Farghaly M, Kanawati N, Mathew A, al-Bader A, Van Dalen A
- Issue date: 2000 Jan-Mar
- Preoperative serum levels of CEA and CA 19-9 and their prognostic significance in colorectal carcinoma.
- Authors: Reiter W, Stieber P, Reuter C, Nagel D, Lau-Werner U, Pahl H, Fateh-Moghadam A
- Issue date: 1997 Jul-Aug
- Prognostic significance of CTCs and CSCs of tumor drainage vein blood in Dukes' stage B and C colorectal cancer patients.
- Authors: Shimada R, Iinuma H, Akahane T, Horiuchi A, Watanabe T
- Issue date: 2012 Apr