Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy.
Affiliation
The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX.Issue Date
1978
Metadata
Show full item recordAbstract
Thirty-eight patients with metastatic melanoma were evaluated immunologically prior to chemoimmunotherapy. The assays used included recall antigen skin hypersensitivity; lymphocyte count; nonspecific T, non-T, and K cell lymphocytotoxicity; and T and B cell rosette enumeration. Survival curves were computed for each of four ranges of values of a given immunologic test. The higher ranges of positive skin tests, lymphocyte count, cytotoxicity, and T and B subpopulation numbers were consistently associated with the longer survivals. The differences reached statistical significance for non-T cell cytotoxicity and B and T cell peripheral blood counts. Pretreatment immune reactivity, particularly that involvingg non-T cell function, appears related to length of survival.Citation
Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy. 1978, 4 (1):59-70 Med. Pediatr. Oncol.Journal
Medical and Pediatric OncologyPubMed ID
625264Type
ArticleLanguage
enISSN
0098-1532Collections
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