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    Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy.

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    Authors
    Thatcher, Nick
    Palmer, Michael K
    Swindell, Ric
    Crowther, Derek
    Affiliation
    The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX.
    Issue Date
    1978
    
    Metadata
    Show full item record
    Abstract
    Thirty-eight patients with metastatic melanoma were evaluated immunologically prior to chemoimmunotherapy. The assays used included recall antigen skin hypersensitivity; lymphocyte count; nonspecific T, non-T, and K cell lymphocytotoxicity; and T and B cell rosette enumeration. Survival curves were computed for each of four ranges of values of a given immunologic test. The higher ranges of positive skin tests, lymphocyte count, cytotoxicity, and T and B subpopulation numbers were consistently associated with the longer survivals. The differences reached statistical significance for non-T cell cytotoxicity and B and T cell peripheral blood counts. Pretreatment immune reactivity, particularly that involvingg non-T cell function, appears related to length of survival.
    Citation
    Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy. 1978, 4 (1):59-70 Med. Pediatr. Oncol.
    Journal
    Medical and Pediatric Oncology
    URI
    http://hdl.handle.net/10541/108705
    PubMed ID
    625264
    Type
    Article
    Language
    en
    ISSN
    0098-1532
    Collections
    All Christie Publications

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