Lack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy.
dc.contributor.author | West, Catharine M L | |
dc.contributor.author | Davidson, Susan E | |
dc.contributor.author | Pool, Claire | |
dc.contributor.author | James, Roger D | |
dc.contributor.author | Schofield, Philip F | |
dc.date.accessioned | 2010-07-27T15:35:45Z | |
dc.date.available | 2010-07-27T15:35:45Z | |
dc.date.issued | 1991-05 | |
dc.identifier.citation | Lack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy. 1991, 126 (2):260-3 Radiat. Res. | en |
dc.identifier.issn | 0033-7587 | |
dc.identifier.pmid | 2023996 | |
dc.identifier.uri | http://hdl.handle.net/10541/108457 | |
dc.description.abstract | The relationship between in vitro radiation sensitivity and colony-forming efficiency has been examined for primary human tumors of the cervix, colorectum, and lymph gland. Tumors were cultured using the Courtenay-Mills soft agar clonogenic assay and radiosensitivity was assessed as surviving fraction at 2 Gy. There was no correlation between colony-forming efficiency and surviving fraction at 2 Gy, giving confidence to the use of surviving fraction at 2 Gy as a predictor of clinical outcome. | |
dc.language.iso | en | en |
dc.subject | Cancer | en |
dc.subject | Colonic Cancer | en |
dc.subject | Rectal Cancer | en |
dc.subject | Tumour Stem Cell Assay | en |
dc.subject | Uterine Cervical Cancer | en |
dc.subject.mesh | Cell Survival | |
dc.subject.mesh | Cesium Radioisotopes | |
dc.subject.mesh | Colonic Neoplasms | |
dc.subject.mesh | Female | |
dc.subject.mesh | Gamma Rays | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Rectal Neoplasms | |
dc.subject.mesh | Tumor Stem Cell Assay | |
dc.subject.mesh | Uterine Cervical Neoplasms | |
dc.title | Lack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy. | en |
dc.type | Article | en |
dc.contributor.department | Cancer Research Campaign Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, United Kingdom. | en |
dc.identifier.journal | Radiation Research | en |
html.description.abstract | The relationship between in vitro radiation sensitivity and colony-forming efficiency has been examined for primary human tumors of the cervix, colorectum, and lymph gland. Tumors were cultured using the Courtenay-Mills soft agar clonogenic assay and radiosensitivity was assessed as surviving fraction at 2 Gy. There was no correlation between colony-forming efficiency and surviving fraction at 2 Gy, giving confidence to the use of surviving fraction at 2 Gy as a predictor of clinical outcome. |