Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature.
Authors
Gibbons, BMacCallum, P
Watts, E
Rohatiner, Ama
Webb, D
Katz, F E
Secker-Walker, L M
Temperley, I J
Harrison, Christine J
Campbell, Richard H A
Affiliation
Department of Medical Oncology, St Bartholomew's Hospital, London, UK.Issue Date
1991-09
Metadata
Show full item recordAbstract
Seven new cases are described of near haploid acute lymphoblastic leukemia (ALL) and the findings reviewed together with updated complete remission duration and survival data for the 21 cases already published. The patients were four males and three females, with an age range 2-19 years; all had an immunophenotype consistent with common ALL. The poor prognostic outlook for patients with near haploid ALL is confirmed by the median remission duration of 14 months for these patients, which is comparable to that for the previously published cases. The pattern of chromosome loss was marked particularly by the presence of two copies of chromosomes 10, 14, 18, 21 and both sex chromosomes. Populations of hyperdiploid cells with double the near haploid number were observed in six of the patients, one of whom demonstrated further clonal evolution, and it is proposed that some cases classified as hyperdiploid ALL with greater than 50 chromosomes may also have arisen from a near haploid stem line.Citation
Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature. 1991, 5 (9):738-43 LeukemiaJournal
LeukemiaPubMed ID
1943226Type
ArticleLanguage
enISSN
0887-6924Collections
Related articles
- Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia.
- Authors: Chen C, Bartenhagen C, Gombert M, Okpanyi V, Binder V, Röttgers S, Bradtke J, Teigler-Schlegel A, Harbott J, Ginzel S, Thiele R, Fischer U, Dugas M, Hu J, Borkhardt A
- Issue date: 2013 Jun
- Chromosome evolution of near-haploid clones in an established human acute lymphoblastic leukemia cell line (NALM-16).
- Authors: Kohno S, Minowada J, Sandberg AA
- Issue date: 1980 Mar
- Near haploid childhood acute lymphoblastic leukemia masked by hyperdiploid line: detection by fluorescence in situ hybridization.
- Authors: Stark B, Jeison M, Gobuzov R, Krug H, Glaser-Gabay L, Luria D, El-Hasid R, Harush MB, Avrahami G, Fisher S, Stein J, Zaizov R, Yaniv I
- Issue date: 2001 Jul 15
- [Adult acute lymphoblastic leukemia presenting a near haploid karyotype].
- Authors: Kimura M, Yufu Y, Kawano R, Goto T, Takatsuki H, Uike N
- Issue date: 2000 Sep
- Loss of chromosomes is the primary event in near-haploid and low-hypodiploid acute lymphoblastic leukemia.
- Authors: Safavi S, Forestier E, Golovleva I, Barbany G, Nord KH, Moorman AV, Harrison CJ, Johansson B, Paulsson K
- Issue date: 2013 Jan