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    Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature.

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    Authors
    Gibbons, B
    MacCallum, P
    Watts, E
    Rohatiner, Ama
    Webb, D
    Katz, F E
    Secker-Walker, L M
    Temperley, I J
    Harrison, Christine J
    Campbell, Richard H A
    Affiliation
    Department of Medical Oncology, St Bartholomew's Hospital, London, UK.
    Issue Date
    1991-09
    
    Metadata
    Show full item record
    Abstract
    Seven new cases are described of near haploid acute lymphoblastic leukemia (ALL) and the findings reviewed together with updated complete remission duration and survival data for the 21 cases already published. The patients were four males and three females, with an age range 2-19 years; all had an immunophenotype consistent with common ALL. The poor prognostic outlook for patients with near haploid ALL is confirmed by the median remission duration of 14 months for these patients, which is comparable to that for the previously published cases. The pattern of chromosome loss was marked particularly by the presence of two copies of chromosomes 10, 14, 18, 21 and both sex chromosomes. Populations of hyperdiploid cells with double the near haploid number were observed in six of the patients, one of whom demonstrated further clonal evolution, and it is proposed that some cases classified as hyperdiploid ALL with greater than 50 chromosomes may also have arisen from a near haploid stem line.
    Citation
    Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature. 1991, 5 (9):738-43 Leukemia
    Journal
    Leukemia
    URI
    http://hdl.handle.net/10541/108432
    PubMed ID
    1943226
    Type
    Article
    Language
    en
    ISSN
    0887-6924
    Collections
    All Christie Publications

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