Comparative intraperitoneal pharmacokinetics of three platinum analogues.
dc.contributor.author | Lind, Michael J | |
dc.contributor.author | Murphy, D J | |
dc.contributor.author | Sharma, H | |
dc.contributor.author | Tinker, N | |
dc.contributor.author | Smith, A | |
dc.contributor.author | McAuliffe, C A | |
dc.contributor.author | Crowther, Derek | |
dc.date.accessioned | 2010-07-27T13:17:48Z | |
dc.date.available | 2010-07-27T13:17:48Z | |
dc.date.issued | 1991 | |
dc.identifier.citation | Comparative intraperitoneal pharmacokinetics of three platinum analogues. 1991, 28 (4):315-7 Cancer Chemother. Pharmacol | en |
dc.identifier.issn | 0344-5704 | |
dc.identifier.pmid | 1879050 | |
dc.identifier.doi | 10.1007/BF00685543 | |
dc.identifier.uri | http://hdl.handle.net/10541/108406 | |
dc.description.abstract | The pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer or fallopian tube carcinoma by following the disposition of tracer doses of 195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist. | |
dc.language.iso | en | en |
dc.subject | Fallopian Tube Cancer | en |
dc.subject | Ovarian Cancer | en |
dc.subject.mesh | Antineoplastic Agents | |
dc.subject.mesh | Carboplatin | |
dc.subject.mesh | Cisplatin | |
dc.subject.mesh | Fallopian Tube Neoplasms | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Infusions, Parenteral | |
dc.subject.mesh | Organoplatinum Compounds | |
dc.subject.mesh | Ovarian Neoplasms | |
dc.subject.mesh | Platinum | |
dc.subject.mesh | Radioisotopes | |
dc.subject.mesh | Time Factors | |
dc.title | Comparative intraperitoneal pharmacokinetics of three platinum analogues. | en |
dc.type | Article | en |
dc.contributor.department | CRC Department of Medical Oncology, Christie Hospital, Manchester, UK. | en |
dc.identifier.journal | Cancer Chemotherapy and Pharmacology | en |
html.description.abstract | The pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer or fallopian tube carcinoma by following the disposition of tracer doses of 195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist. |