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dc.contributor.authorLind, Michael J
dc.contributor.authorMurphy, D J
dc.contributor.authorSharma, H
dc.contributor.authorTinker, N
dc.contributor.authorSmith, A
dc.contributor.authorMcAuliffe, C A
dc.contributor.authorCrowther, Derek
dc.date.accessioned2010-07-27T13:17:48Z
dc.date.available2010-07-27T13:17:48Z
dc.date.issued1991
dc.identifier.citationComparative intraperitoneal pharmacokinetics of three platinum analogues. 1991, 28 (4):315-7 Cancer Chemother. Pharmacolen
dc.identifier.issn0344-5704
dc.identifier.pmid1879050
dc.identifier.doi10.1007/BF00685543
dc.identifier.urihttp://hdl.handle.net/10541/108406
dc.description.abstractThe pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer or fallopian tube carcinoma by following the disposition of tracer doses of 195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist.
dc.language.isoenen
dc.subjectFallopian Tube Canceren
dc.subjectOvarian Canceren
dc.subject.meshAntineoplastic Agents
dc.subject.meshCarboplatin
dc.subject.meshCisplatin
dc.subject.meshFallopian Tube Neoplasms
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfusions, Parenteral
dc.subject.meshOrganoplatinum Compounds
dc.subject.meshOvarian Neoplasms
dc.subject.meshPlatinum
dc.subject.meshRadioisotopes
dc.subject.meshTime Factors
dc.titleComparative intraperitoneal pharmacokinetics of three platinum analogues.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalCancer Chemotherapy and Pharmacologyen
html.description.abstractThe pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer or fallopian tube carcinoma by following the disposition of tracer doses of 195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist.


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