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    Fludarabine phosphate for the treatment of low grade lymphoid malignancy.

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    Authors
    Whelan, J S
    Davis, C L
    Rule, S
    Ranson, Malcolm R
    Smith, O P
    Mehta, A B
    Catovsky, D
    Rohatiner, A Z
    Lister, T A
    Affiliation
    ICRF Department of Medical Oncology, St Bartholomew's Hospital, London, UK.
    Issue Date
    1991-07
    
    Metadata
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    Abstract
    Thirty-four patients with previously treated, advanced, low grade NHL were treated with Fludarabine, a deamination-resistant analogue of adenosine arabinoside, at a dose of 25 mg m-2 intravenously, daily for 5 days (median number of cycles = 3, range 1-10). Complete remission (CR) was achieved in six and partial remission (PR) in a further seven. Overall, responses were seen in 11/23 patients (48%) with follicular lymphoma and in 2/11 (18%) with low grade, diffuse NHL. Fifteen patients with previously treated CLL and one patient with prolymphocytic leukaemia (PLL) were also treated as above (median no. of cycles = 3, range 1-6). A partial response was seen in three of the 11 evaluable patients with CLL and CR was achieved in the patient with PLL. There were four deaths due to infection and 19 further episodes requiring admission to hospital. No other significant toxicity was reported in a total of 164 cycles of Fludarabine. This agent is active in advanced low grade lymphoid malignancy. Further studies are required to assess its role in newly diagnosed patients.
    Citation
    Fludarabine phosphate for the treatment of low grade lymphoid malignancy. 1991, 64 (1):120-3 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/108390
    PubMed ID
    1713049
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications

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