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    Effect of in vivo administration of interferon gamma on expression of MHC products and tumour associated antigens in patients with metastatic melanoma.

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    Authors
    Ghosh, Anna K
    Cerny, T
    Wagstaff, John
    Thatcher, Nick
    Moore, M
    Affiliation
    Department of Immunology, Paterson Institute for Cancer Research, Manchester, U.K.
    Issue Date
    1989-11
    
    Metadata
    Show full item record
    Abstract
    IFN-gamma is an effective inducer of MHC class II antigen expression in cell lines of malignant melanoma. To investigate the possibility that IFN-gamma may increase MHC class I and II and melanoma tumour associated antigens in vivo, immunohistochemical analyses of biopsies from six patients with metastatic disease undergoing IFN-gamma treatment were performed. Before IFN-gamma treatment, the melanomas were class I positive and class II negative. After treatment, class I expression was neither enhanced nor class II expression induced in any tissue sample regardless of biopsy time or dose of IFN-gamma. TAA was similarly unchanged. However, in one of the six patients a primary cell line was established and IFN-gamma induced expression of MHC products. The possible reasons for lack of MHC induction are discussed, although qualitative changes in antigen expression cannot be excluded on the basis of qualitative immunocytochemical techniques alone.
    Citation
    Effect of in vivo administration of interferon gamma on expression of MHC products and tumour associated antigens in patients with metastatic melanoma. 1989, 25 (11):1637-43 Eur J Cancer Clin Oncol
    Journal
    European Journal of Cancer & Clinical Oncology
    URI
    http://hdl.handle.net/10541/108138
    PubMed ID
    2512172
    Type
    Article
    Language
    en
    ISSN
    0277-5379
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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