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dc.contributor.authorThatcher, Nicken
dc.contributor.authorSwindell, Ricen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T15:21:32Z
dc.date.available2010-07-21T15:21:32Z
dc.date.issued1979-05
dc.identifier.citationEffects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions. 1979, 36 (2):227-36 Clin. Exp. Immunol.en
dc.identifier.issn0009-9104
dc.identifier.pmid314367
dc.identifier.urihttp://hdl.handle.net/10541/108102
dc.description.abstractIncreased lymphocyte cytotoxicity, particularly of 'killer' K cell type was recorded with repeated immunizations of either C. parvum or BCG. A 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. No marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. Expression of cytotoxicity results as percentage 51Cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymphocyte curves) are described. A 3 week immunization schedule is suggested where BCG and C. parvum are used as immunotherapeutic agents, in the doses quoted.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBCG Vaccine
dc.subject.meshBacterial Vaccines
dc.subject.meshCytotoxicity, Immunologic
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshHypersensitivity, Delayed
dc.subject.meshImmunization Schedule
dc.subject.meshKiller Cells, Natural
dc.subject.meshLeukocyte Count
dc.subject.meshLymphocytes
dc.subject.meshMale
dc.subject.meshMelanoma
dc.subject.meshMiddle Aged
dc.subject.meshPropionibacterium acnes
dc.subject.meshT-Lymphocytes
dc.titleEffects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions.en
dc.typeArticleen
dc.identifier.journalClinical and Experimental Immunologyen
html.description.abstractIncreased lymphocyte cytotoxicity, particularly of 'killer' K cell type was recorded with repeated immunizations of either C. parvum or BCG. A 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. No marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. Expression of cytotoxicity results as percentage 51Cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymphocyte curves) are described. A 3 week immunization schedule is suggested where BCG and C. parvum are used as immunotherapeutic agents, in the doses quoted.


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