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dc.contributor.authorThatcher, Nick
dc.contributor.authorGasiunas, Nijole
dc.contributor.authorCrowther, Derek
dc.date.accessioned2010-07-21T15:06:15Z
dc.date.available2010-07-21T15:06:15Z
dc.date.issued1977
dc.identifier.citationLymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology. 1977, 3 (3):311-21 Med. Pediatr. Oncol.en
dc.identifier.issn0098-1532
dc.identifier.pmid311411
dc.identifier.doi10.1002/mpo.2950030313
dc.identifier.urihttp://hdl.handle.net/10541/108095
dc.description.abstractLymphocytotoxicity of T, non-T and K cells was found to be diminished in a proportion of 30 patients with untreated non-Hodgkin lymphoma; T cell number as enumerated by E sheep cell rosettes was also reduced. The reduction was greatest in patients with disease of unfavorable pathology; the effect of stage on these tests was not marked. Decreased skin reactivity was found in the same group of patients with unfavorable pathology. The reduction of direct and antibody dependent lymphocytotoxicity was not related to an obvious reduction in non-T cell numbers, as assessed by rosetting tests. There was, however, a decrease in phytohemagglutinin cytotoxicity in those groups with reduced T cell number. The influence of unfavorable pathology on lymphocyte effector function is emphasized by this study.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntibody-Dependent Cell Cytotoxicity
dc.subject.meshCytotoxicity Tests, Immunologic
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphocytes
dc.subject.meshLymphoma
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRosette Formation
dc.subject.meshSkin Tests
dc.subject.meshT-Lymphocytes
dc.titleLymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology.en
dc.typeArticleen
dc.contributor.department1Cancer Research Campaign Department of Medical Oncology of Manchester University, Christie Hospital and Holt Radium Institute, Withington, Manchester, England.en
dc.identifier.journalMedical and Pediatric Oncologyen
html.description.abstractLymphocytotoxicity of T, non-T and K cells was found to be diminished in a proportion of 30 patients with untreated non-Hodgkin lymphoma; T cell number as enumerated by E sheep cell rosettes was also reduced. The reduction was greatest in patients with disease of unfavorable pathology; the effect of stage on these tests was not marked. Decreased skin reactivity was found in the same group of patients with unfavorable pathology. The reduction of direct and antibody dependent lymphocytotoxicity was not related to an obvious reduction in non-T cell numbers, as assessed by rosetting tests. There was, however, a decrease in phytohemagglutinin cytotoxicity in those groups with reduced T cell number. The influence of unfavorable pathology on lymphocyte effector function is emphasized by this study.


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