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    Lymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology.

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    Authors
    Thatcher, Nick
    Gasiunas, Nijole
    Crowther, Derek
    Affiliation
    1Cancer Research Campaign Department of Medical Oncology of Manchester University, Christie Hospital and Holt Radium Institute, Withington, Manchester, England.
    Issue Date
    1977
    
    Metadata
    Show full item record
    Abstract
    Lymphocytotoxicity of T, non-T and K cells was found to be diminished in a proportion of 30 patients with untreated non-Hodgkin lymphoma; T cell number as enumerated by E sheep cell rosettes was also reduced. The reduction was greatest in patients with disease of unfavorable pathology; the effect of stage on these tests was not marked. Decreased skin reactivity was found in the same group of patients with unfavorable pathology. The reduction of direct and antibody dependent lymphocytotoxicity was not related to an obvious reduction in non-T cell numbers, as assessed by rosetting tests. There was, however, a decrease in phytohemagglutinin cytotoxicity in those groups with reduced T cell number. The influence of unfavorable pathology on lymphocyte effector function is emphasized by this study.
    Citation
    Lymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology. 1977, 3 (3):311-21 Med. Pediatr. Oncol.
    Journal
    Medical and Pediatric Oncology
    URI
    http://hdl.handle.net/10541/108095
    DOI
    10.1002/mpo.2950030313
    PubMed ID
    311411
    Type
    Article
    Language
    en
    ISSN
    0098-1532
    ae974a485f413a2113503eed53cd6c53
    10.1002/mpo.2950030313
    Scopus Count
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    All Christie Publications

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