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    Lymphocyte function and response to chemo-immunotherapy in patients with metastatic melanoma.

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    Authors
    Thatcher, Nick
    Palmer, Michael K
    Gasiunas, Nijole
    Crowther, Derek
    Affiliation
    Cancer Research Campaign Department of Medical Oncology of Manchester University.
    Issue Date
    1977-12
    
    Metadata
    Show full item record
    Abstract
    Thirty-eight patients with metastatic melanoma were investigated for lymphocyte function immediately prior to chemo-immunotherapy. The pre-treatment immune tests were compared with normal control values and with response to therapy. The "non-responder" group (but not "responder") had significantly reduced values for lymphocyte, null-cell and E-rosette-cell counts compared with controls. Lymphocytoxicity ( using a Chang target cell) showed the same pattern, with depression of direct and K-cell cytotoxic capacity in non-responders compared with controls. Eight patients were studied sequentially whilst on treatment, and demonstrated considerable change (not statistically significant) in lymphocytotoxicity, an untreated "control" patient showed little variation. "Recall"-antigen skin testing showed no statistically significant difference between the patient groups. The data indicate that "non-T-cell activity" may be associated with response to chemo-immunotherapy.
    Citation
    Lymphocyte function and response to chemo-immunotherapy in patients with metastatic melanoma. 1977, 36 (6):751-62 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/108091
    PubMed ID
    597473
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications

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