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    Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly study of melanoma patients II. Changes in serum immunoglobulins and lymphoid cell subpopulations.

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    Authors
    Thatcher, Nick
    Swindell, Ric
    Crowther, Derek
    Affiliation
    Cancer Research Campaign, Department of Medical Oncology of Manchester University.
    Issue Date
    1979-06
    
    Metadata
    Show full item record
    Abstract
    Two groups, each of eight patients, with metastatic melanoma were immunized with either C. parvum or BCG at 3-weekly intervals. The serum IgG, IgA, IgM levels, E-rosettes, EA-rosetts, sIg-bearing cells, 'null cells' and lymphocyte blastogenesis at four PHA concentrations were assayed, before immunization and weekly thereafter for 8 weeks. The pre-immunization E-rosette values were significantly reduced, with a significant increase in 'null cell' values and EA-rosette percentages, when compared with healthy controls. Following C. parvum immunization, significant increases occurred in E-rosette percentages with decreases in EA-rosette and 'null cell' counts. A significant reduction in 'null cell' values also occurred with BCG. Other parameters including PHA blastogenesis did not exhibit statistically significant changes. Different methods of expressing the results (particularly of blastogenesis data) were compared, as were the similarities between the present investigation and a study of the effects of a single immunization. The relationship between the subpopulation changes and lymphocyte cytotoxicity described in an earlier article (Thatcher, Swindell & Crowther, 1979a) is discussed.
    Citation
    Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly study of melanoma patients II. Changes in serum immunoglobulins and lymphoid cell subpopulations. 1979, 36 (3):456-64 Clin. Exp. Immunol.
    Journal
    Clinical and Experimental Immunology
    URI
    http://hdl.handle.net/10541/108088
    PubMed ID
    487647
    Type
    Article
    Language
    en
    ISSN
    0009-9104
    Collections
    All Christie Publications

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