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dc.contributor.authorWagstaff, John
dc.contributor.authorGibson, C
dc.contributor.authorThatcher, Nick
dc.contributor.authorCrowther, Derek
dc.date.accessioned2010-07-21T14:12:40Z
dc.date.available2010-07-21T14:12:40Z
dc.date.issued1981-10
dc.identifier.citationThe migratory properties of indium-111 oxine labelled lymphocytes in patients with chronic lymphocytic leukaemia. 1981, 49 (2):283-91 Br. J. Haematol.en
dc.identifier.issn0007-1048
dc.identifier.pmid7295582
dc.identifier.urihttp://hdl.handle.net/10541/108082
dc.description.abstractThese studies describe the application of a new method for following the migration of autologous lymphocytes in normal subjects and patients with chronic lymphocytic leukaemia (CLL). There is evidence that Indium 111 oxine is a reliable radioactive cell label for in vivo studies of lymphocyte traffic in man. In normal subjects, where 60-70% of the lymphocytes labelled are T cells, the results are different from those of previous workers. The lymphocytes leave the blood initially but later return to it. It is believed that this is due to the reappearance of cells which at first entered the spleen. It is suggested that the difference between these data and those of Hersey (1971) is due to the failure of lymphocytes in the latter studies to return to the blood after primary migration. In CLL no such reappearance in the blood is seen and the lymphocytes do not leave the spleen in significant numbers over 48 h. This suggests that CLL B cells either do not recirculate through spleen or that their transit time is greater than 48 h. Bone marrow localization in CLL patients is greater than in the normal subjects, suggesting that either a larger proportion of the neoplastic B lymphocytes enter this compartment or their transit time through it is longer than the transit time of a normal T cell predominant population. Localization in normal-sized lymph nodes in patients with CLL is less than that in the lymph nodes of normal subjects. This may possibly be explained by the greater propensity of T lymphocytes to enter lymph nodes than B lymphocytes, or by the altered migratory properties of CLL B lymphocytes as compared with normal B cells.
dc.language.isoenen
dc.subjectLymphoid Leukaemiaen
dc.subject.meshAdult
dc.subject.meshBone Marrow
dc.subject.meshCell Movement
dc.subject.meshHumans
dc.subject.meshIndium
dc.subject.meshLeukemia, Lymphoid
dc.subject.meshLiver
dc.subject.meshLymph Nodes
dc.subject.meshLymphocytes
dc.subject.meshMiddle Aged
dc.subject.meshOrganometallic Compounds
dc.subject.meshOxyquinoline
dc.subject.meshSpleen
dc.titleThe migratory properties of indium-111 oxine labelled lymphocytes in patients with chronic lymphocytic leukaemia.en
dc.typeArticleen
dc.identifier.journalBritish Journal of Haematologyen
html.description.abstractThese studies describe the application of a new method for following the migration of autologous lymphocytes in normal subjects and patients with chronic lymphocytic leukaemia (CLL). There is evidence that Indium 111 oxine is a reliable radioactive cell label for in vivo studies of lymphocyte traffic in man. In normal subjects, where 60-70% of the lymphocytes labelled are T cells, the results are different from those of previous workers. The lymphocytes leave the blood initially but later return to it. It is believed that this is due to the reappearance of cells which at first entered the spleen. It is suggested that the difference between these data and those of Hersey (1971) is due to the failure of lymphocytes in the latter studies to return to the blood after primary migration. In CLL no such reappearance in the blood is seen and the lymphocytes do not leave the spleen in significant numbers over 48 h. This suggests that CLL B cells either do not recirculate through spleen or that their transit time is greater than 48 h. Bone marrow localization in CLL patients is greater than in the normal subjects, suggesting that either a larger proportion of the neoplastic B lymphocytes enter this compartment or their transit time through it is longer than the transit time of a normal T cell predominant population. Localization in normal-sized lymph nodes in patients with CLL is less than that in the lymph nodes of normal subjects. This may possibly be explained by the greater propensity of T lymphocytes to enter lymph nodes than B lymphocytes, or by the altered migratory properties of CLL B lymphocytes as compared with normal B cells.


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