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    A comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent.

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    Authors
    Carroll, K B
    Moussalli, H
    Brown, D
    Thatcher, Nick
    Affiliation
    Regional Cardiothoracic Unit, Wythenshawe Hospital, Southmoore Road, Manchester 23 UK.
    Issue Date
    1983-04
    
    Metadata
    Show full item record
    Abstract
    Sixty-eight patients with inoperable but 'limited' stage small-cell carcinoma of the bronchus were treated with two different chemotherapy regimens. Thirty-four patients received methotrexate, cyclophosphamide, procarbazine and vincristine in standard dose over a 2-year schedule. Thirty-four patients received cyclophosphamide alone over a period of 3 months. The groups were evenly balanced with respect to clinical details which are fully described. Toxicity was acceptable. The median actual survival for the whole group was 11 months, the 1-year, 2-year and 4-year survival being 48%, 30% and 1.5% respectively. There was no statistically significant difference in survival between those classified as responders and those as non-responders, nor between the groups treated with the two different regimens. There was a high local recurrence rate.
    Citation
    A comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent. 1983, 77 (2):171-8 Br J Dis Chest
    Journal
    British Journal of Diseases of the Chest
    URI
    http://hdl.handle.net/10541/108073
    DOI
    10.1016/0007-0971(83)90024-4
    PubMed ID
    6307334
    Type
    Article
    Language
    en
    ISSN
    0007-0971
    ae974a485f413a2113503eed53cd6c53
    10.1016/0007-0971(83)90024-4
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