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dc.contributor.authorThatcher, Nicken
dc.contributor.authorSwindell, Ricen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T14:52:27Z
dc.date.available2010-07-21T14:52:27Z
dc.date.issued1979-01
dc.identifier.citationEffects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. I. Changes in blood counts, serum immunoglobulins and lymphoid cell populations. 1979, 35 (1):36-44 Clin. Exp. Immunol.en
dc.identifier.issn0009-9104
dc.identifier.pmid428146
dc.identifier.urihttp://hdl.handle.net/10541/108071
dc.description.abstractThe effects of a single immunization of melanoma patients with BCG or C. parvum on the blood counts, serum immunoglobulin levels and lymphoid subpopulations were followed by multiple assays over 28 days. C. parvum produced a decrease in the white cell count, lymphocyte count and lymphoid T and sIg+ cell numbers, which recovered within 1 week; BCG did not produce such a marked depression. Both agents were associated with increases in T cell numbers and lymphocyte PHA blastogenesis after the first week; these declined to pre-immunization values by 3-4 weeks. The sIg-bearing cell subpopulation also increased after BCG. Different methods of expression the results were compared and the difficulties of immunological monitoring are discussed.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBCG Vaccine
dc.subject.meshBacterial Vaccines
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunoglobulins
dc.subject.meshLeukocyte Count
dc.subject.meshLymphocyte Activation
dc.subject.meshMale
dc.subject.meshMelanoma
dc.subject.meshMiddle Aged
dc.subject.meshPhytohemagglutinins
dc.subject.meshPropionibacterium acnes
dc.subject.meshReceptors, Antigen, B-Cell
dc.subject.meshRosette Formation
dc.titleEffects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. I. Changes in blood counts, serum immunoglobulins and lymphoid cell populations.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign, Department of Medical Oncology, University of Manchester.en
dc.identifier.journalClinical and Experimental Immunologyen
html.description.abstractThe effects of a single immunization of melanoma patients with BCG or C. parvum on the blood counts, serum immunoglobulin levels and lymphoid subpopulations were followed by multiple assays over 28 days. C. parvum produced a decrease in the white cell count, lymphocyte count and lymphoid T and sIg+ cell numbers, which recovered within 1 week; BCG did not produce such a marked depression. Both agents were associated with increases in T cell numbers and lymphocyte PHA blastogenesis after the first week; these declined to pre-immunization values by 3-4 weeks. The sIg-bearing cell subpopulation also increased after BCG. Different methods of expression the results were compared and the difficulties of immunological monitoring are discussed.


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