A phase II study of cyclophosphamide as a 24-hr infusion in advanced non-small cell lung cancer.
AffiliationDepartment of Medical Oncology, Christie Hospital, Manchester M20 9BX, U.K.
MetadataShow full item record
AbstractTwenty patients with progressive non-small cell lung cancer who had received no prior chemotherapy were treated with 24-hr infusions of cyclophosphamide at a dose of 2.5 g/m2. The median number of courses administered was three (range one to six). There was one PR and one CR, an overall response rate of 10% (95% confidence limits 2-32%). A further six patients experienced excellent relief of distressing symptoms, unresponsive to other measures, as a result of the chemotherapy. The median survival for the 20 patients was 18.5 weeks (range 4-75 weeks). The median leukocyte nadir count was 1.1 X 10(9)/1 and median platelet nadir count 226 X 10(9)/1. There were no episodes of cystitis and gastrointestinal toxicity was moderate. This study has not shown any advantage for the infusion schedule over conventional bolus regimens, but further dose escalation or more prolonged infusion times may improve results.
CitationA phase II study of cyclophosphamide as a 24-hr infusion in advanced non-small cell lung cancer. 1986, 22 (4):435-7 Eur J Cancer Clin Oncol
JournalEuropean Journal of Cancer & Clinical Oncology
- Phase I trial of granulocyte-macrophage colony-stimulating factor plus high-dose cyclophosphamide given every 2 weeks: a Cancer and Leukemia Group B study.
- Authors: Lichtman SM, Ratain MJ, Van Echo DA, Rosner G, Egorin MJ, Budman DR, Vogelzang NJ, Norton L, Schilsky RL
- Issue date: 1993 Aug 18
- Phase I clinical and pharmacokinetic study of cyclophosphamide administered by five-day continuous intravenous infusion.
- Authors: Tchekmedyian NS, Egorin MJ, Cohen BE, Kaplan RS, Poplin E, Aisner J
- Issue date: 1986
- High-dose infusional doxorubicin and cyclophosphamide: a feasibility study of tandem high-dose chemotherapy cycles without stem cell support.
- Authors: Morgan RJ Jr, Doroshow JH, Venkataraman K, Chang K, Raschko J, Somlo G, Leong L, Tetef M, Shibata S, Hamasaki V, Margolin K, Forman S, Akman S, Coluzzi P, Ahn C, Weiss L, Gadgil U, Harrison J
- Issue date: 1997 Dec
- A phase II study of ifosfamide in combination with etoposide and cisplatin in the treatment of extensive small cell lung cancer.
- Authors: Evans WK, Stewart D, Logan D, Maroun J, Goss G, Shepherd FA, Latreille J, Warner E, Dahrouge S
- Issue date: 1992 Dec
- Double alkylating agent therapy with ifosfamide and cyclophosphamide for advanced non-small cell lung cancer. From the Manchester Lung Tumour Group.
- Authors: Thatcher N, Smith DB, Lind MJ, Anderson H, Barclay J, Chopra MP, Fitzgerald MD
- Issue date: 1988 Jan 1