Show simple item record

dc.contributor.authorCerny, T
dc.contributor.authorBarnes, Diana M
dc.contributor.authorHasleton, Philip S
dc.contributor.authorBarber, Philip V
dc.contributor.authorHealy, K
dc.contributor.authorGullick, W
dc.contributor.authorThatcher, Nick
dc.date.accessioned2010-07-21T10:11:22Z
dc.date.available2010-07-21T10:11:22Z
dc.date.issued1986-08
dc.identifier.citationExpression of epidermal growth factor receptor (EGF-R) in human lung tumours. 1986, 54 (2):265-9 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid3017396
dc.identifier.urihttp://hdl.handle.net/10541/108028
dc.description.abstractEpidermal growth factor receptor (EGF-R) expression was assessed in 63 lung tumour samples with a monoclonal antibody (EGF-R1) by indirect immunoperoxidase staining on cryostat sections. All 15 small cell lung cancer samples were negative whereas over 80% of the 48 non small lung cancer stained positively. In 30 bronchial biopsies two monoclonal antibodies against the cytoplasmic part of the EGF-R were evaluated. These antibodies showed weaker staining than EGF-R1. No additional or enhanced staining as compared with EGF-R1 was observed, suggesting a lack of enhanced expression of a truncated EGF-R analogous to the v-erb-B oncogene product. Monoclonal antibodies against the EGF-R may be helpful diagnostically in differentiating small cell from non small cell lung cancer and may also be important in elucidating biological differences in primary lung cancer.
dc.language.isoenen
dc.subject.meshAdenocarcinoma
dc.subject.meshAntibodies, Monoclonal
dc.subject.meshCarcinoma, Small Cell
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshEpidermal Growth Factor
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshLung Neoplasms
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshReceptor, Epidermal Growth Factor
dc.subject.meshReceptors, Cell Surface
dc.titleExpression of epidermal growth factor receptor (EGF-R) in human lung tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren
html.description.abstractEpidermal growth factor receptor (EGF-R) expression was assessed in 63 lung tumour samples with a monoclonal antibody (EGF-R1) by indirect immunoperoxidase staining on cryostat sections. All 15 small cell lung cancer samples were negative whereas over 80% of the 48 non small lung cancer stained positively. In 30 bronchial biopsies two monoclonal antibodies against the cytoplasmic part of the EGF-R were evaluated. These antibodies showed weaker staining than EGF-R1. No additional or enhanced staining as compared with EGF-R1 was observed, suggesting a lack of enhanced expression of a truncated EGF-R analogous to the v-erb-B oncogene product. Monoclonal antibodies against the EGF-R may be helpful diagnostically in differentiating small cell from non small cell lung cancer and may also be important in elucidating biological differences in primary lung cancer.


This item appears in the following Collection(s)

Show simple item record