• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Expression of epidermal growth factor receptor (EGF-R) in human lung tumours.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Cerny, T
    Barnes, Diana M
    Hasleton, Philip S
    Barber, Philip V
    Healy, K
    Gullick, W
    Thatcher, Nick
    Affiliation
    Department of Medical Oncology, Christie Hospital, Manchester, UK.
    Issue Date
    1986-08
    
    Metadata
    Show full item record
    Abstract
    Epidermal growth factor receptor (EGF-R) expression was assessed in 63 lung tumour samples with a monoclonal antibody (EGF-R1) by indirect immunoperoxidase staining on cryostat sections. All 15 small cell lung cancer samples were negative whereas over 80% of the 48 non small lung cancer stained positively. In 30 bronchial biopsies two monoclonal antibodies against the cytoplasmic part of the EGF-R were evaluated. These antibodies showed weaker staining than EGF-R1. No additional or enhanced staining as compared with EGF-R1 was observed, suggesting a lack of enhanced expression of a truncated EGF-R analogous to the v-erb-B oncogene product. Monoclonal antibodies against the EGF-R may be helpful diagnostically in differentiating small cell from non small cell lung cancer and may also be important in elucidating biological differences in primary lung cancer.
    Citation
    Expression of epidermal growth factor receptor (EGF-R) in human lung tumours. 1986, 54 (2):265-9 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/108028
    PubMed ID
    3017396
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Epidermal growth factor receptors in non-small cell lung cancer.
    • Authors: Veale D, Ashcroft T, Marsh C, Gibson GJ, Harris AL
    • Issue date: 1987 May
    • Expression of epidermal growth factor receptors in four histologic cell types of lung cancer.
    • Authors: Kaseda S, Ueda M, Ozawa S, Ishihara T, Abe O, Shimizu N
    • Issue date: 1989 Sep
    • Epidermal growth factor receptors in lung tumours.
    • Authors: Berger MS, Gullick WJ, Greenfield C, Evans S, Addis BJ, Waterfield MD
    • Issue date: 1987 Aug
    • Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival.
    • Authors: Dazzi H, Hasleton PS, Thatcher N, Barnes DM, Wilkes S, Swindell R, Lawson RA
    • Issue date: 1989 May
    • [Immunohistochemical studies on epidermal growth factor receptor and the myc oncogene product in squamous cell carcinoma of the uterine cervix].
    • Authors: Yamasaki M, Maruo T, Akahori T, Mochizuki M
    • Issue date: 1988 Jan
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.