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dc.contributor.authorCerny, Ten
dc.contributor.authorFey, M Fen
dc.contributor.authorOppliger, Ren
dc.contributor.authorCastiglione, Men
dc.contributor.authorNachbur, Ben
dc.contributor.authorGertsch, Men
dc.contributor.authorGasser, Aen
dc.contributor.authorJoss, R Aen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorLind, Michael Jen
dc.contributor.authorVon Rohr, Aen
dc.date.accessioned2010-07-21T09:27:32Z
dc.date.available2010-07-21T09:27:32Z
dc.date.issued1992-09-30
dc.identifier.citationPrevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC). 1992, 52 (3):504-6 Int J Canceren
dc.identifier.issn0020-7136
dc.identifier.pmid1328070
dc.identifier.urihttp://hdl.handle.net/10541/108025
dc.description.abstractWe report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK). In contrast, the Rh-negative phenotype is no more frequent in non-small-cell lung cancer patients or in heavy smokers with coronary heart disease than in the general population. There was a normal distribution of the ABO blood group phenotype in all patients studied. Whilst the significance of this observation is unclear, we hypothesize that a genetic predisposition to the development of SCLC may be linked to a hitherto unidentified gene on chromosome 1p near the Rh locus. Our observation may perhaps allow further progress to be made in understanding genetic mechanisms of SCLC carcinogenesis.
dc.language.isoenen
dc.subjectLung Canceren
dc.subject.meshABO Blood-Group System
dc.subject.meshCarcinoma, Small Cell
dc.subject.meshEuropean Continental Ancestry Group
dc.subject.meshHumans
dc.subject.meshLung Neoplasms
dc.subject.meshPhenotype
dc.subject.meshPrevalence
dc.subject.meshRh-Hr Blood-Group System
dc.titlePrevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC).en
dc.typeArticleen
dc.contributor.departmentInstitute of Medical Oncology, Inselspital, Berne, Switzerland.en
dc.identifier.journalInternational Journal of Canceren
html.description.abstractWe report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK). In contrast, the Rh-negative phenotype is no more frequent in non-small-cell lung cancer patients or in heavy smokers with coronary heart disease than in the general population. There was a normal distribution of the ABO blood group phenotype in all patients studied. Whilst the significance of this observation is unclear, we hypothesize that a genetic predisposition to the development of SCLC may be linked to a hitherto unidentified gene on chromosome 1p near the Rh locus. Our observation may perhaps allow further progress to be made in understanding genetic mechanisms of SCLC carcinogenesis.


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