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    Prevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC).

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    Authors
    Cerny, T
    Fey, M F
    Oppliger, R
    Castiglione, M
    Nachbur, B
    Gertsch, M
    Gasser, A
    Joss, R A
    Thatcher, Nick
    Lind, Michael J
    Von Rohr, A
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    Affiliation
    Institute of Medical Oncology, Inselspital, Berne, Switzerland.
    Issue Date
    1992-09-30
    
    Metadata
    Show full item record
    Abstract
    We report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK). In contrast, the Rh-negative phenotype is no more frequent in non-small-cell lung cancer patients or in heavy smokers with coronary heart disease than in the general population. There was a normal distribution of the ABO blood group phenotype in all patients studied. Whilst the significance of this observation is unclear, we hypothesize that a genetic predisposition to the development of SCLC may be linked to a hitherto unidentified gene on chromosome 1p near the Rh locus. Our observation may perhaps allow further progress to be made in understanding genetic mechanisms of SCLC carcinogenesis.
    Citation
    Prevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC). 1992, 52 (3):504-6 Int J Cancer
    Journal
    International Journal of Cancer
    URI
    http://hdl.handle.net/10541/108025
    PubMed ID
    1328070
    Type
    Article
    Language
    en
    ISSN
    0020-7136
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    All Christie Publications

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