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    Treatment of malignant pleural effusions with intrapleural Corynebacterium parvum or tetracycline.

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    Authors
    Leahy, B
    Honeybourne, D
    Brear, S G
    Carroll, K B
    Thatcher, Nick
    Stretton, T B
    Issue Date
    1985-01
    
    Metadata
    Show full item record
    Abstract
    Thirty two patients with malignant pleural effusion were randomly allocated to treatment with intrapleural Corynebacterium parvum or tetracycline hydrochloride in an attempt to prevent symptomatic recurrence of pleural fluid. Success in preventing recurrence of fluid at one month, using up to 2 doses of each drug, was 14 of 16 cases for Corynebacterium parvum, 5 of 9 for tetracycline given via an intercostal needle, and 6 of 7 for tetracycline given through an intercostal tube. These difference were not statistically significant. Corynebacterium parvum was significantly more likely to produce pyrexia equal or greater than 38 degrees C (P less than 0.001) and pain requiring analgesia (P less than 0.05) than tetracycline hydrochloride. Corynebacterium parvum is a useful agent for the management of malignant pleural effusion, but is associated with more side effects than tetracycline.
    Citation
    Treatment of malignant pleural effusions with intrapleural Corynebacterium parvum or tetracycline. 1985, 66 (1):50-4 Eur J Respir Dis
    Journal
    European Journal of Respiratory Diseases
    URI
    http://hdl.handle.net/10541/108011
    PubMed ID
    3979476
    Type
    Article
    Language
    en
    ISSN
    0106-4339
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    All Christie Publications

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