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    Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients.

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    Authors
    Cerny, T
    Blair, Val
    Anderson, Heather
    Bramwell, Vivien H C
    Thatcher, Nick
    Affiliation
    Institut fuer Medizinische Onkologie, Universitaet Bern, Inselspital, CH-3010 Bern, Switzerland
    Issue Date
    1987-02-15
    
    Metadata
    Show full item record
    Abstract
    In 407 patients with small-cell lung cancer (SCLC), 61 pretreatment variables were evaluated in a Cox multiple regression analysis to assess their prognostic value. All patients received short-term intensive regimens (cyclophosphamide, etoposide and methotrexate or ifosfamide and etoposide, both followed by thoracic irradiation if complete response was noted). Lactate dehydrogenase (p = 0.001), tumour stage (p = 0.0001), serum sodium (p = 0.0009), pretreatment Karnofsky performance score (p = 0.0121), alkaline phosphatase (p = 0.0186) and serum bicarbonate (p = 0.0321) were the important prognostic factors. Once these variables were taken into account no other variable provided additional prognostic information. A simple scoring system ("Manchester Score") using these variables was established and shows little loss of information compared to the Cox analysis. The score distinguishes 3 prognostic groups, the best of which contains all long-term survivors, whereas the bad prognostic group contains no patient surviving longer than one year. The scoring system may help to design new treatment strategies and may also facilitate the comparison of different studies.
    Citation
    Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients. 1987, 39 (2):146-9 Int. J. Cancer
    Journal
    International Journal of Cancer
    URI
    http://hdl.handle.net/10541/108003
    DOI
    10.1002/ijc.2910390204
    PubMed ID
    3026969
    Type
    Article
    Language
    en
    ISSN
    0020-7136
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.2910390204
    Scopus Count
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    All Christie Publications

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