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    The effect of age on the pharmacokinetics of ifosfamide.

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    Authors
    Lind, Michael J
    Margison, Jennifer M
    Cerny, T
    Thatcher, Nick
    Wilkinson, Peter M
    Affiliation
    Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester.
    Issue Date
    1990-07
    
    Metadata
    Show full item record
    Abstract
    The effect of age on the pharmacokinetics of ifosfamide was studied in 20 patients with advanced non small cell lung cancer. A positive correlation was found between the elimination half-life of ifosfamide and age (r = 0.48, 0.05 less than P less than 0.01). This was due to an increase in volume of distribution with age (r = 0.66, 0.001 less than P less than 0.01). Total plasma clearance, renal clearance and non renal clearance did not change with age. Age did not affect the autoinduction of ifosfamide metabolism. Further studies are needed to demonstrate any adverse effects of ifosfamide in the elderly.
    Citation
    The effect of age on the pharmacokinetics of ifosfamide. 1990, 30 (1):140-3 Br J Clin Pharmacol
    Journal
    British Journal of Clinical Pharmacology
    URI
    http://hdl.handle.net/10541/107674
    PubMed ID
    2167716
    Type
    Article
    Language
    en
    ISSN
    0306-5251
    Collections
    All Christie Publications

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