DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival.
| dc.contributor.author | Dazzi, H | |
| dc.contributor.author | Thatcher, Nick | |
| dc.contributor.author | Hasleton, Philip S | |
| dc.contributor.author | Swindell, Ric | |
| dc.date.accessioned | 2010-07-14T16:26:26Z | |
| dc.date.available | 2010-07-14T16:26:26Z | |
| dc.date.issued | 1990-05 | |
| dc.identifier.citation | DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival. 1990, 84 (3):217-23 Respir Med | en |
| dc.identifier.issn | 0954-6111 | |
| dc.identifier.pmid | 2171051 | |
| dc.identifier.uri | http://hdl.handle.net/10541/107655 | |
| dc.description.abstract | In a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor. | |
| dc.language.iso | en | en |
| dc.subject | Cancer DNA | en |
| dc.subject | Lung Cancer | en |
| dc.subject.mesh | Carcinoma, Non-Small-Cell Lung | |
| dc.subject.mesh | DNA, Neoplasm | |
| dc.subject.mesh | Flow Cytometry | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Lung Neoplasms | |
| dc.subject.mesh | Ploidies | |
| dc.subject.mesh | Prognosis | |
| dc.subject.mesh | Receptor, Epidermal Growth Factor | |
| dc.subject.mesh | Retrospective Studies | |
| dc.title | DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival. | en |
| dc.type | Article | en |
| dc.contributor.department | CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K. | en |
| dc.identifier.journal | Respiratory Medicine | en |
| html.description.abstract | In a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor. |