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dc.contributor.authorDazzi, Hen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorHasleton, Philip Sen
dc.contributor.authorSwindell, Ricen
dc.date.accessioned2010-07-14T16:26:26Z
dc.date.available2010-07-14T16:26:26Z
dc.date.issued1990-05
dc.identifier.citationDNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival. 1990, 84 (3):217-23 Respir Meden
dc.identifier.issn0954-6111
dc.identifier.pmid2171051
dc.identifier.urihttp://hdl.handle.net/10541/107655
dc.description.abstractIn a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor.
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectLung Canceren
dc.subject.meshCarcinoma, Non-Small-Cell Lung
dc.subject.meshDNA, Neoplasm
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshLung Neoplasms
dc.subject.meshPloidies
dc.subject.meshPrognosis
dc.subject.meshReceptor, Epidermal Growth Factor
dc.subject.meshRetrospective Studies
dc.titleDNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.en
dc.identifier.journalRespiratory Medicineen
html.description.abstractIn a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor.


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