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    DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival.

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    Authors
    Dazzi, H
    Thatcher, Nick
    Hasleton, Philip S
    Swindell, Ric
    Affiliation
    CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
    Issue Date
    1990-05
    
    Metadata
    Show full item record
    Abstract
    In a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor.
    Citation
    DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival. 1990, 84 (3):217-23 Respir Med
    Journal
    Respiratory Medicine
    URI
    http://hdl.handle.net/10541/107655
    PubMed ID
    2171051
    Type
    Article
    Language
    en
    ISSN
    0954-6111
    Collections
    All Christie Publications

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