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dc.contributor.authorLind, Michael J
dc.contributor.authorRoberts, H L
dc.contributor.authorThatcher, Nick
dc.contributor.authorIdle, J R
dc.date.accessioned2010-07-14T16:08:18Z
dc.date.available2010-07-14T16:08:18Z
dc.date.issued1990
dc.identifier.citationThe effect of route of administration and fractionation of dose on the metabolism of ifosfamide. 1990, 26 (2):105-11 Cancer Chemother Pharmacolen
dc.identifier.issn0344-5704
dc.identifier.pmid2347037
dc.identifier.urihttp://hdl.handle.net/10541/107653
dc.description.abstractThe measurement of urinary ifosfamide, isophosphoramide mustard, dechloroethyl ifosfamide and carboxyifosfamide using high-performance thin-layer chromatography with photographic densitometry (TLC-PD) is described. This technique was also used to demonstrate the large inter-individual variation in the ifosfamide metabolic profile of patients receiving the drug as single-agent therapy for non-small-cell lung cancer. In addition, oral administration was shown to result in higher levels of these metabolites in the urine. Fractionation of the ifosfamide dose over several days resulted in increasing levels of metabolites in the urine, consistent with auto-induction of ifosfamide metabolism.
dc.language.isoenen
dc.subject.meshAdministration, Oral
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntineoplastic Agents
dc.subject.meshChromatography, Thin Layer
dc.subject.meshCyclophosphamide
dc.subject.meshDensitometry
dc.subject.meshDrug Administration Schedule
dc.subject.meshHumans
dc.subject.meshIfosfamide
dc.subject.meshInfusions, Intravenous
dc.subject.meshMiddle Aged
dc.subject.meshPhosphoramide Mustards
dc.titleThe effect of route of administration and fractionation of dose on the metabolism of ifosfamide.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute Manchester, UK.en
dc.identifier.journalCancer Chemotherapy and Pharmacologyen
html.description.abstractThe measurement of urinary ifosfamide, isophosphoramide mustard, dechloroethyl ifosfamide and carboxyifosfamide using high-performance thin-layer chromatography with photographic densitometry (TLC-PD) is described. This technique was also used to demonstrate the large inter-individual variation in the ifosfamide metabolic profile of patients receiving the drug as single-agent therapy for non-small-cell lung cancer. In addition, oral administration was shown to result in higher levels of these metabolites in the urine. Fractionation of the ifosfamide dose over several days resulted in increasing levels of metabolites in the urine, consistent with auto-induction of ifosfamide metabolism.


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