The effect of route of administration and fractionation of dose on the metabolism of ifosfamide.
AffiliationCRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute Manchester, UK.
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AbstractThe measurement of urinary ifosfamide, isophosphoramide mustard, dechloroethyl ifosfamide and carboxyifosfamide using high-performance thin-layer chromatography with photographic densitometry (TLC-PD) is described. This technique was also used to demonstrate the large inter-individual variation in the ifosfamide metabolic profile of patients receiving the drug as single-agent therapy for non-small-cell lung cancer. In addition, oral administration was shown to result in higher levels of these metabolites in the urine. Fractionation of the ifosfamide dose over several days resulted in increasing levels of metabolites in the urine, consistent with auto-induction of ifosfamide metabolism.
CitationThe effect of route of administration and fractionation of dose on the metabolism of ifosfamide. 1990, 26 (2):105-11 Cancer Chemother Pharmacol
JournalCancer Chemotherapy and Pharmacology
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