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dc.contributor.authorRadford, John A
dc.contributor.authorMargison, Jennifer M
dc.contributor.authorSwindell, Ric
dc.contributor.authorLind, Michael J
dc.contributor.authorWilkinson, Peter M
dc.contributor.authorThatcher, Nick
dc.date.accessioned2010-07-14T16:10:08Z
dc.date.available2010-07-14T16:10:08Z
dc.date.issued1990
dc.identifier.citationThe stability of ifosfamide in aqueous solution and its suitability for continuous 7-day infusion by ambulatory pump. 1990, 26 (2):144-6 Cancer Chemother Pharmacolen
dc.identifier.issn0344-5704
dc.identifier.pmid2347040
dc.identifier.urihttp://hdl.handle.net/10541/107649
dc.description.abstractDose fractionation is known to reduce the toxicity of ifosfamide and also results in an increased production of alkylating metabolites. Administration by slow infusion using the convenience of ambulatory pumps is therefore of interest. We used HPLC to investigate the stability of ifosfamide in aqueous solution (either alone, solution A, or mixed with mesna, solution B) under various conditions over a 9-day period. At both ambient temperature in daylight and 27 degrees C in a dark environment, there was no evidence of ifosfamide decay in either solution. However, at 37 degrees C in a dark environment, a fall was detected in both solutions, which at 9 days amounted to a loss of 7% of the amount of ifosfamide present at time zero. At 70 degrees C, levels of ifosfamide in both solutions fell within 72 h to markedly lower levels than controls, thus confirming that the methods used were indicative of stability. We conclude that ifosfamide, either alone or mixed with mesna, is stable for 9 days at temperatures up to 27 degrees C; even at 37 degrees C, the measured loss is small. The continuous infusion of ifosfamide over 7 days by ambulatory pump is now a practical proposition.
dc.language.isoenen
dc.subject.meshAmbulatory Care
dc.subject.meshChromatography, High Pressure Liquid
dc.subject.meshDrug Stability
dc.subject.meshHumans
dc.subject.meshIfosfamide
dc.subject.meshInfusion Pumps
dc.subject.meshSolutions
dc.subject.meshTime Factors
dc.subject.meshWater
dc.titleThe stability of ifosfamide in aqueous solution and its suitability for continuous 7-day infusion by ambulatory pump.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalCancer Chemotherapy and Pharmacologyen
html.description.abstractDose fractionation is known to reduce the toxicity of ifosfamide and also results in an increased production of alkylating metabolites. Administration by slow infusion using the convenience of ambulatory pumps is therefore of interest. We used HPLC to investigate the stability of ifosfamide in aqueous solution (either alone, solution A, or mixed with mesna, solution B) under various conditions over a 9-day period. At both ambient temperature in daylight and 27 degrees C in a dark environment, there was no evidence of ifosfamide decay in either solution. However, at 37 degrees C in a dark environment, a fall was detected in both solutions, which at 9 days amounted to a loss of 7% of the amount of ifosfamide present at time zero. At 70 degrees C, levels of ifosfamide in both solutions fell within 72 h to markedly lower levels than controls, thus confirming that the methods used were indicative of stability. We conclude that ifosfamide, either alone or mixed with mesna, is stable for 9 days at temperatures up to 27 degrees C; even at 37 degrees C, the measured loss is small. The continuous infusion of ifosfamide over 7 days by ambulatory pump is now a practical proposition.


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