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    Ifosfamide, doxorubicin and etoposide in small cell lung cancer patients with poor prognosis.

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    Authors
    Kamthan, A G
    Lind, Michael J
    Thatcher, Nick
    Steward, William P
    Bronchud, M H
    Ranson, Malcolm R
    Stout, Ronald
    Affiliation
    Department of Medical Oncology, Christie Hospital, Manchester, U.K.
    Issue Date
    1990
    
    Metadata
    Show full item record
    Abstract
    61 patients with small cell lung cancer in a poor prognosis group were treated with chemotherapy and with thoracic radiotherapy if they had 'limited stage' disease. No prophylactic cranial irradiation was given. Chemotherapy comprised doxorubicin 50 mg/m2 and ifosfamide 5 g/m2 with mesna on day 1, and etoposide 120 mg/m2 intravenously on days 1 and 2 and 240 mg/m2 orally on day 3. Treatment was repeated every 3 weeks for a maximum of six courses and no dosage reductions were allowed. Complete response rate in limited stage patients was 55% and 16% in extensive stage patients. The partial responses were 38% and 66% respectively. Overall median survival was 10.5 months with 2-year survival of 14%. The corresponding values for limited stage disease were 13 months and 16% and for extensive stage disease 8 months and 13%. Despite the addition of doxorubicin at a somewhat higher dosage than usual in this type of regimen and a policy of no dose reduction, toxicity was generally mild. There was, however, a 19% relapse rate in complete responders in the brain, apparently as the sole site of disease.
    Citation
    Ifosfamide, doxorubicin and etoposide in small cell lung cancer patients with poor prognosis. 1990, 26 (6):691-4 Eur J Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/107648
    PubMed ID
    2168191
    Type
    Article
    Language
    en
    ISSN
    0959-8049
    Collections
    All Christie Publications

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