Changes in body composition in men and women with advanced nonsmall cell lung cancer (NSCLC) undergoing chemotherapy.
dc.contributor.author | Harvie, Michelle N | |
dc.contributor.author | Campbell, I T | |
dc.contributor.author | Thatcher, Nick | |
dc.contributor.author | Baildam, Andrew D | |
dc.date.accessioned | 2010-07-12T15:43:25Z | |
dc.date.available | 2010-07-12T15:43:25Z | |
dc.date.issued | 2003-10 | |
dc.identifier.citation | Changes in body composition in men and women with advanced nonsmall cell lung cancer (NSCLC) undergoing chemotherapy. 2003, 16 (5):323-6 J Hum Nutr Diet | en |
dc.identifier.issn | 0952-3871 | |
dc.identifier.pmid | 14516379 | |
dc.identifier.uri | http://hdl.handle.net/10541/107471 | |
dc.description.abstract | BACKGROUND: Men with nonsmall cell lung cancer (NSCLC) are more susceptible to weight loss than women. The composition and aetiology of these gender specific weight changes are not known. METHODS: Measurements of body mass, body composition and energy balance (resting energy expenditure and energy intake) were made in 15 men and six women before and after chemotherapy for NSCLC. RESULTS: Over the course of chemotherapy minimal weight change was observed in both men and women. Men increased body fat from 25.0 +/- 5.5 to 27.9 +/- 7.9% (P < 0.05) whereas fat free mass (FFM) tended to decrease (P = 0.063). There was no change in body fat or FFM in the women. In the men resting energy expenditure decreased over the course of chemotherapy from 113.2 +/- 15.9 to 105.1 +/- 10.1% of the value predicted from the Harris Benedict equation (P < 0.05). In the women resting energy expenditure (REE) did not alter. CONCLUSION: Over the course of chemotherapy for NSCLC, men and women appear to have different patterns of change in body composition and in energy expenditure. | |
dc.language.iso | en | en |
dc.subject | Lung Cancer | en |
dc.subject.mesh | Adipose Tissue | |
dc.subject.mesh | Antineoplastic Agents | |
dc.subject.mesh | Body Composition | |
dc.subject.mesh | Carcinoma, Non-Small-Cell Lung | |
dc.subject.mesh | Energy Intake | |
dc.subject.mesh | Energy Metabolism | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Lung Neoplasms | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Muscle, Skeletal | |
dc.subject.mesh | Prospective Studies | |
dc.subject.mesh | Sex Factors | |
dc.title | Changes in body composition in men and women with advanced nonsmall cell lung cancer (NSCLC) undergoing chemotherapy. | en |
dc.type | Article | en |
dc.contributor.department | University Departments of Anaesthesia Medical Oncology Surgery, South Manchester University Hospitals NHS Trust, Manchester M20 2LR, UK. m_harvie@fs1.with.man.ac.uk | en |
dc.identifier.journal | Journal of human nutrition and dietetics : the official journal of the British Dietetic Association | en |
html.description.abstract | BACKGROUND: Men with nonsmall cell lung cancer (NSCLC) are more susceptible to weight loss than women. The composition and aetiology of these gender specific weight changes are not known. METHODS: Measurements of body mass, body composition and energy balance (resting energy expenditure and energy intake) were made in 15 men and six women before and after chemotherapy for NSCLC. RESULTS: Over the course of chemotherapy minimal weight change was observed in both men and women. Men increased body fat from 25.0 +/- 5.5 to 27.9 +/- 7.9% (P < 0.05) whereas fat free mass (FFM) tended to decrease (P = 0.063). There was no change in body fat or FFM in the women. In the men resting energy expenditure decreased over the course of chemotherapy from 113.2 +/- 15.9 to 105.1 +/- 10.1% of the value predicted from the Harris Benedict equation (P < 0.05). In the women resting energy expenditure (REE) did not alter. CONCLUSION: Over the course of chemotherapy for NSCLC, men and women appear to have different patterns of change in body composition and in energy expenditure. |