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    Symptomatic benefit from gemcitabine and other chemotherapy in advanced non-small cell lung cancer: changes in performance status and tumour-related symptoms.

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    Authors
    Thatcher, Nick
    Anderson, Heather
    Betticher, Daniel C
    Ranson, Malcolm R
    Affiliation
    CRC Department of Medical Oncology, University of Manchester, UK.
    Issue Date
    1995-12
    
    Metadata
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    Abstract
    Results from recent trials challenge the traditional view that chemotherapy offers no survival or quality of life benefits over best supportive care. Meta-analyses of recent trials reveal a modest survival benefit for combination chemotherapy over best supportive care, although there is no strong evidence from randomized trials for superiority of combination over single-agent therapy. In chemotherapy trials where data on performance status change were collected, performance status improved in one-third of patients and remained constant in a further third. Fewer studies have measured changes in specific disease-related symptoms, but there are data from studies with gemcitabine which show improvements in a range of symptoms, including cough, haemoptysis, pain, dyspnoea and anorexia. Thus more patients benefit from chemotherapy than may be suggested by objective response. Surveys have shown that patients are more likely to accept intensive chemotherapy for what are perceived by health care professionals as potentially small benefits. Studies have shown evidence of cost savings associated with chemotherapy over best supportive care.
    Citation
    Symptomatic benefit from gemcitabine and other chemotherapy in advanced non-small cell lung cancer: changes in performance status and tumour-related symptoms. 1995, 6 Suppl 6:39-48 Anticancer Drugs
    Journal
    Anticancer Drugs
    URI
    http://hdl.handle.net/10541/107470
    PubMed ID
    8718424
    Type
    Article
    Language
    en
    ISSN
    0959-4973
    Collections
    All Christie Publications

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