Medicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the clinic.
Authors
Fox, Brian WAffiliation
Paterson Institute for Cancer Research, Christie Hospital, Withington, Manchester, UK.Issue Date
1991
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Show full item recordAbstract
The development of anticancer agents has, in the past, relied heavily on leads derived from screening a wide variety of agents from both synthetic and natural sources. With the development of new techniques of measurement of biochemical changes in cells and the advent of molecular biological techniques, it is becoming clear that many naturally occurring agents, specifically selected for their tumour growth inhibiting activity, are highly complex and novel substances which are potentially promising as anticancer agents in the clinic. The process of getting a drug from the laboratory bench to the clinic is itself often complex due to adverse physical characteristics of the drug. The experience of the Cancer Research Campaign Clinical Trials Committee in developing several natural products, currently in various stages of development for clinical trial, is described. The drugs discussed include the vinca alkaloids, maytansine, combretastatins, bryostatin 1, pancratistatin, phyllanthoside, dolastatin 10, and taxol.Citation
Medicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the clinic., 85 (1):22-5 Trans. R. Soc. Trop. Med. Hyg.Journal
Transactions of the Royal Society of Tropical Medicine and HygieneDOI
10.1016/0035-9203(91)90140-TPubMed ID
2068749Type
ArticleLanguage
enISSN
0035-9203ae974a485f413a2113503eed53cd6c53
10.1016/0035-9203(91)90140-T
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