• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Growth inhibitory effects of transforming growth factor-beta 1 in vivo.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Migdalska, Agnieszka
    Molineux, Graham
    Demuynck, Hilde
    Evans, Gareth S
    Ruscetti, F
    Dexter, T Michael
    Affiliation
    Department of Experimental Haematology, Paterson Institute for Cancer Research, Manchester, England.
    Issue Date
    1991
    
    Metadata
    Show full item record
    Abstract
    Transforming growth factor-beta (TGF-beta) can reversibly inhibit the in vitro proliferation of murine and human haemopoietic progenitors and some of their more developmentally restricted progeny. Using an assay for measuring day 8 and day 11 CFU-S, TGF-beta caused a gradual decline in the number of CFU-S undergoing DNA synthesis so that after 5 days of daily treatment only quiescent cells were found. Release of this growth inhibition was seen within 24 hours post-treatment with recovery of all progenitors to normal levels. Similar inhibitory effects of TGF-beta were seen on the cells of the intestinal epithelium, indicating that TGF-beta is a general stem cell growth inhibitor. These results suggest that TGF-beta can be used as a cytostatic agent to protect normal stem cells in patients being treated with cell cycle-specific cytotoxic agents.
    Citation
    Growth inhibitory effects of transforming growth factor-beta 1 in vivo. 1991, 4 (3):239-45 Growth Factors
    Journal
    Growth Factors
    URI
    http://hdl.handle.net/10541/104699
    DOI
    10.3109/08977199109104820
    PubMed ID
    1768436
    Type
    Article
    Language
    en
    ISSN
    0897-7194
    ae974a485f413a2113503eed53cd6c53
    10.3109/08977199109104820
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • A fraction unresponsive to growth inhibition by TGF-beta among the high-proliferative potential progenitor cells in bone marrow of p53-deficient mice.
    • Authors: Sasaki H, Matsuda M, Lu Y, Ikuta K, Matsuyama S, Hirabayashi Y, Mitsui H, Matsumura T, Muramatsu M, Tsukada T, Aizawa S, Inoue T
    • Issue date: 1997 Feb
    • Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin.
    • Authors: Grzegorzewski K, Ruscetti FW, Usui N, Damia G, Longo DL, Carlino JA, Keller JR, Wiltrout RH
    • Issue date: 1994 Sep 1
    • The effects of transforming growth factor beta 3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood.
    • Authors: Strife A, Lambek C, Perez A, Darzynkiewicz Z, Skierski J, Gulati S, Haley JD, ten Dijke P, Iwata KK, Clarkson BD
    • Issue date: 1991 Sep 15
    • Selective inhibition of primitive hemopoietic colony-forming cells by an extract from normal marrow: comparison with transforming growth factor-beta.
    • Authors: Hampson J, Redmond S, Lord BI, Slocombe P, O'Farrell AM, Heyworth CM, Dexter TM
    • Issue date: 1991 May
    • Inhibition of hematopoietic colony-forming cells. Normal bone marrow extract versus transforming growth factor-beta 1.
    • Authors: Hampson J, Lord BI, Redmond S, Slocombe P
    • Issue date: 1991
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.