• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The radiosensitivity of populations of murine hemopoietic colony-forming cells that respond to combinations of growth factors.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Baird, M C
    Hendry, Jolyon H
    Dexter, T Michael
    Testa, Nydia G
    Affiliation
    Cancer Research Campaign Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
    Issue Date
    1991-05
    
    Metadata
    Show full item record
    Abstract
    Combinations of murine recombinant interleukin 3 (IL-3), purified murine macrophage colony-stimulating factor (M-CSF), and human recombinant interleukin 1 alpha (IL-1 alpha) were used to determine the effects of growth factors on the measured radiosensitivity of different populations of murine colony-forming cells (CFC). The data showed that combinations of growth factors resulted in different values of CFC radiosensitivity, being less than values observed when colony growth was stimulated using a single factor. For various combinations of growth factors, Do values ranged from 106 +/- 8 to 175 +/- 24 cGy for progenitor cells in normal bone marrow; 74 +/- 3 to 171 +/- 18 cGy for primitive multipotent CFC enriched using fluorescence-activated cell sorting; and from 46 +/- 4 to 131 +/- 10 cGy for more mature granulocyte-macrophage CFC, enriched by counterflow centrifugal elutriation. Only combinations of three factors produced the high values of Do reported in experiments using unpurified conditioned medium as a stimulus for colony formation.
    Citation
    The radiosensitivity of populations of murine hemopoietic colony-forming cells that respond to combinations of growth factors. 1991, 19 (4):282-7 Exp. Hematol.
    Journal
    Experimental Hematology
    URI
    http://hdl.handle.net/10541/104695
    PubMed ID
    2055293
    Type
    Article
    Language
    en
    ISSN
    0301-472X
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • The relationship between different high proliferative potential colony-forming cells in mouse bone marrow.
    • Authors: Kriegler AB, Verschoor SM, Bernardo D, Bertoncello I
    • Issue date: 1994 May
    • Radiosensitivity increases with differentiation status of murine hemopoietic progenitor cells selected using enriched marrow subpopulations and recombinant growth factors.
    • Authors: Baird MC, Hendry JH, Testa NG
    • Issue date: 1990 Sep
    • The resolution, enrichment, and organization of normal bone marrow high proliferative potential colony-forming cell subsets on the basis of rhodamine-123 fluorescence.
    • Authors: Bertoncello I, Bradley TR, Hodgson GS, Dunlop JM
    • Issue date: 1991 Mar
    • Progenitor cells in murine bone marrow stimulated by growth factors produced by the AF1-19T rat cell line.
    • Authors: Kriegler AB, Bradley TR, Bertoncello I, Hamilton JA, Hart PH, Piccoli DS, Hodgson GS
    • Issue date: 1990 Jun
    • Stem cell responses in myelosuppressed mice following sequential treatment with recombinant human interleukin 1 (rHuIL-1), recombinant murine interleukin 3 (rMuIL-3) and recombinant human macrophage colony-stimulating factor (rHuM-CSF).
    • Authors: Kovacs CJ, Harrell JP, Evans MJ, Abernathy RS, Roberts CJ, Johnke RM
    • Issue date: 1994 Jan
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.