Show simple item record

dc.contributor.authorGibson, D F
dc.contributor.authorRoberts, Stephen A
dc.contributor.authorEvans, Gareth S
dc.date.accessioned2010-06-11T10:56:54Z
dc.date.available2010-06-11T10:56:54Z
dc.date.issued1991
dc.identifier.citationChanges in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment. 1991, 27 (10):1295-301 Eur. J. Canceren
dc.identifier.issn0959-8049
dc.identifier.pmid1835602
dc.identifier.urihttp://hdl.handle.net/10541/104686
dc.description.abstractThe genital tract epithelium of the female laboratory mouse has been widely studied as a model of oestrogen-dependent growth and proliferation. Perturbation of the hormonal imprinting of these tissues during neonatal development has also been used to study the development of pathological abnormalities, particularly in the cervical epithelium. This study demonstrates that mice treated neonatally from days 1-5 with supraphysiological concentrations of oestrogen are able to maintain high levels of proliferation following the removal of the ovaries later in adult life. This high level of proliferation was shown to be independent of the ovarian oestrogens and of oestrogens produced peripherally by aromatisation. These results suggest conversion of the genital tract in these mice to a fully hormonal "independent" state. However, neonatal treatment with oestrogen was not found to produce a uniform change to hormonal independence. Further challenge of the adult ovariectomised mice with oestrogen, demonstrated that a population of cells still retained the ability to respond to the mitogenic influence of this hormone.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshAnimals, Newborn
dc.subject.meshAromatase
dc.subject.meshCell Count
dc.subject.meshCell Division
dc.subject.meshEpithelium
dc.subject.meshEstradiol
dc.subject.meshFemale
dc.subject.meshGenitalia, Female
dc.subject.meshMice
dc.subject.meshMice, Inbred Strains
dc.subject.meshOvariectomy
dc.subject.meshThymidine
dc.titleChanges in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment.en
dc.typeArticleen
dc.contributor.departmentDepartment of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.en
dc.identifier.journalEuropean Journal of Canceren
html.description.abstractThe genital tract epithelium of the female laboratory mouse has been widely studied as a model of oestrogen-dependent growth and proliferation. Perturbation of the hormonal imprinting of these tissues during neonatal development has also been used to study the development of pathological abnormalities, particularly in the cervical epithelium. This study demonstrates that mice treated neonatally from days 1-5 with supraphysiological concentrations of oestrogen are able to maintain high levels of proliferation following the removal of the ovaries later in adult life. This high level of proliferation was shown to be independent of the ovarian oestrogens and of oestrogens produced peripherally by aromatisation. These results suggest conversion of the genital tract in these mice to a fully hormonal "independent" state. However, neonatal treatment with oestrogen was not found to produce a uniform change to hormonal independence. Further challenge of the adult ovariectomised mice with oestrogen, demonstrated that a population of cells still retained the ability to respond to the mitogenic influence of this hormone.


This item appears in the following Collection(s)

Show simple item record