• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Gibson, D F
    Roberts, Stephen A
    Evans, Gareth S
    Affiliation
    Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.
    Issue Date
    1991
    
    Metadata
    Show full item record
    Abstract
    The genital tract epithelium of the female laboratory mouse has been widely studied as a model of oestrogen-dependent growth and proliferation. Perturbation of the hormonal imprinting of these tissues during neonatal development has also been used to study the development of pathological abnormalities, particularly in the cervical epithelium. This study demonstrates that mice treated neonatally from days 1-5 with supraphysiological concentrations of oestrogen are able to maintain high levels of proliferation following the removal of the ovaries later in adult life. This high level of proliferation was shown to be independent of the ovarian oestrogens and of oestrogens produced peripherally by aromatisation. These results suggest conversion of the genital tract in these mice to a fully hormonal "independent" state. However, neonatal treatment with oestrogen was not found to produce a uniform change to hormonal independence. Further challenge of the adult ovariectomised mice with oestrogen, demonstrated that a population of cells still retained the ability to respond to the mitogenic influence of this hormone.
    Citation
    Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment. 1991, 27 (10):1295-301 Eur. J. Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/104686
    PubMed ID
    1835602
    Type
    Article
    Language
    en
    ISSN
    0959-8049
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Role of stroma in oestrogen-induced epithelial proliferation.
    • Authors: Cunha GR, Young P
    • Issue date: 1992 Jan
    • Effects of postpubertal oestrogen injections on mitotic activity of vaginal and uterine epithelial cells in mice treated neonatally with oestrogen.
    • Authors: Mori T
    • Issue date: 1975 Jan
    • Keratinocyte growth factor injected into female mouse neonates stimulates uterine and vaginal epithelial growth.
    • Authors: Hom YK, Young P, Thomson AA, Cunha GR
    • Issue date: 1998 Sep
    • Effect on neonatal oestrogen and hCG treatment on the genital organs of adult female rats.
    • Authors: Nikolić Z, Blagojević Z, Mrvić V, Ivanov I
    • Issue date: 1999
    • Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium.
    • Authors: Cooke PS, Buchanan DL, Young P, Setiawan T, Brody J, Korach KS, Taylor J, Lubahn DB, Cunha GR
    • Issue date: 1997 Jun 10
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.