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    Dimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity.

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    Authors
    Fox, Brian W
    Hadfield, John A
    O'Connor, P M
    Affiliation
    Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
    Issue Date
    1991-05
    
    Metadata
    Show full item record
    Abstract
    The anti-tumour activities of nine aromatic dimethanesulphonate esters were examined. Their biological effects have been related to both their chemical reactivity and to the computer-modelled vectorial positions of the centres of alkylation of the compounds. One compound (19) has shown activity between sensitive and resistant Yoshida tumours in vivo and also shows the highest activity between these two cell lines in vitro. In its minimal energy form, this compound would require to interact with converging nucleophilic centres about 6 A apart, and it is tentatively suggested that this may be an appropriate dimension for a receptor which is required to be alkylated in order to show anti-tumour activity.
    Citation
    Dimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity. 1991, 6 (2):71-82 Anticancer Drug Des.
    Journal
    Anticancer Drug Design
    URI
    http://hdl.handle.net/10541/104669
    PubMed ID
    2039583
    Type
    Article
    Language
    en
    ISSN
    0266-9536
    Collections
    All Paterson Institute for Cancer Research

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