Dimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity.
AffiliationDepartment of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
MetadataShow full item record
AbstractThe anti-tumour activities of nine aromatic dimethanesulphonate esters were examined. Their biological effects have been related to both their chemical reactivity and to the computer-modelled vectorial positions of the centres of alkylation of the compounds. One compound (19) has shown activity between sensitive and resistant Yoshida tumours in vivo and also shows the highest activity between these two cell lines in vitro. In its minimal energy form, this compound would require to interact with converging nucleophilic centres about 6 A apart, and it is tentatively suggested that this may be an appropriate dimension for a receptor which is required to be alkylated in order to show anti-tumour activity.
CitationDimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity. 1991, 6 (2):71-82 Anticancer Drug Des.
JournalAnticancer Drug Design
- Dimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus.
- Authors: Hadfield JA, Fox BW, Caffrey R
- Issue date: 1992 Jun
- Effect of methyl methanesulphonate (MMS) and methylene dimethanesulphonate (MDMS) on the template activity of DNA isolated from MDMS-sensitive and -resistant Yoshida cells.
- Authors: Institoris E, Fox BW, Fox M
- Issue date: 1975 Dec
- Methyl 2-(2-chloroethylaminocarbonyl)diazenecarboxylate SB-166 inhibits the growth of different tumour cell lines, including drug-resistant sublines.
- Authors: Cimbora T, Bombek S, Polanc S, Osmak M
- Issue date: 2003 Apr
- Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
- Authors: Baraldi PG, Balboni G, Pavani MG, Spalluto G, Tabrizi MA, Clercq ED, Balzarini J, Bando T, Sugiyama H, Romagnoli R
- Issue date: 2001 Aug 2
- Factor-assisted DNA binding as a possible general mechanism for steroid receptors. Functional heterogeneity among activated receptor-steroid complexes.
- Authors: Cavanaugh AH, Simons SS Jr
- Issue date: 1994 Apr