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dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorHeald, J
dc.contributor.authorHarris, Martin
dc.date.accessioned2010-06-09T16:30:19Z
dc.date.available2010-06-09T16:30:19Z
dc.date.issued1991-02
dc.identifier.citationTwelve cases of Ki-1 positive anaplastic large cell lymphoma of skin. 1991, 44 (2):119-25 J. Clin. Pathol.en
dc.identifier.issn0021-9746
dc.identifier.pmid1650796
dc.identifier.doi10.1136/jcp.44.2.119
dc.identifier.urihttp://hdl.handle.net/10541/104536
dc.description.abstractIn seven of 12 cases of Ber-H2 (Ki-1) positive anaplastic large cell non-Hodgkin's lymphoma (Ki-1 ALCL) disease remained localised to skin, and in five there was extracutaneous spread. Four patients had histological evidence of pre-existing or coexisting mycosis fungoides, and three patients had a long standing history of eczema or ichthyosis. In two cases the presence of a T phenotype was shown in frozen sections, and in a further six cases a T phenotype was firmly established in paraffin wax sections. Four patients died less than one year after presentation (two with disseminated lymphoma; two from other causes); one died at five years with widespread lymphoma and the remaining seven cases were alive one to 14 1/2 years after presentation. Three of the four patients with associated mycosis fungoides had prolonged survival, contrary to the findings of previous reports which suggest secondary Ki-1 ALCL behaves aggressively. The recognition of these tumours is important because of their relatively good prognosis. The diagnosis can be readily substantiated immunohistochemically, using a simple panel of antibodies.
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectSkin Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntibodies, Monoclonal
dc.subject.meshAntigens, CD
dc.subject.meshAntigens, CD30
dc.subject.meshAntigens, Neoplasm
dc.subject.meshBiological Markers
dc.subject.meshEczema
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIchthyosis
dc.subject.meshImmunohistochemistry
dc.subject.meshLymph Nodes
dc.subject.meshLymphoma, Large B-Cell, Diffuse
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMycosis Fungoides
dc.subject.meshSkin Neoplasms
dc.titleTwelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital and Holt Radium Institute, Manchester.en
dc.identifier.journalJournal of Clinical Pathologyen
html.description.abstractIn seven of 12 cases of Ber-H2 (Ki-1) positive anaplastic large cell non-Hodgkin's lymphoma (Ki-1 ALCL) disease remained localised to skin, and in five there was extracutaneous spread. Four patients had histological evidence of pre-existing or coexisting mycosis fungoides, and three patients had a long standing history of eczema or ichthyosis. In two cases the presence of a T phenotype was shown in frozen sections, and in a further six cases a T phenotype was firmly established in paraffin wax sections. Four patients died less than one year after presentation (two with disseminated lymphoma; two from other causes); one died at five years with widespread lymphoma and the remaining seven cases were alive one to 14 1/2 years after presentation. Three of the four patients with associated mycosis fungoides had prolonged survival, contrary to the findings of previous reports which suggest secondary Ki-1 ALCL behaves aggressively. The recognition of these tumours is important because of their relatively good prognosis. The diagnosis can be readily substantiated immunohistochemically, using a simple panel of antibodies.


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