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    Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.

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    Authors
    Banerjee, Saumitra S
    Heald, J
    Harris, Martin
    Affiliation
    Department of Histopathology, Christie Hospital and Holt Radium Institute, Manchester.
    Issue Date
    1991-02
    
    Metadata
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    Abstract
    In seven of 12 cases of Ber-H2 (Ki-1) positive anaplastic large cell non-Hodgkin's lymphoma (Ki-1 ALCL) disease remained localised to skin, and in five there was extracutaneous spread. Four patients had histological evidence of pre-existing or coexisting mycosis fungoides, and three patients had a long standing history of eczema or ichthyosis. In two cases the presence of a T phenotype was shown in frozen sections, and in a further six cases a T phenotype was firmly established in paraffin wax sections. Four patients died less than one year after presentation (two with disseminated lymphoma; two from other causes); one died at five years with widespread lymphoma and the remaining seven cases were alive one to 14 1/2 years after presentation. Three of the four patients with associated mycosis fungoides had prolonged survival, contrary to the findings of previous reports which suggest secondary Ki-1 ALCL behaves aggressively. The recognition of these tumours is important because of their relatively good prognosis. The diagnosis can be readily substantiated immunohistochemically, using a simple panel of antibodies.
    Citation
    Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin. 1991, 44 (2):119-25 J. Clin. Pathol.
    Journal
    Journal of Clinical Pathology
    URI
    http://hdl.handle.net/10541/104536
    DOI
    10.1136/jcp.44.2.119
    PubMed ID
    1650796
    Type
    Article
    Language
    en
    ISSN
    0021-9746
    ae974a485f413a2113503eed53cd6c53
    10.1136/jcp.44.2.119
    Scopus Count
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