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    Late BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma.

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    Authors
    Hasleton, Philip S
    O'Driscoll, B R
    Lynch, P
    Webster, A
    Kalra, S J
    Gattamaneni, Rao
    Woodcock, A A
    Poulter, L W
    Affiliation
    Department of Pathology, Wythenshawe Hospital, Manchester, U.K.
    Issue Date
    1991-05
    
    Metadata
    Show full item record
    Abstract
    We describe eight patients who developed interstitial pulmonary fibrosis following BCNU (carmustine) therapy for cerebral tumours. The fibrosis presented 12-17 (mean 14) years after exposure to the drug. A distinctive pattern of pulmonary fibrosis with involvement of the apices and subpleural areas was seen in one patient dying of the disease. Light microscopy showed interstitial elastosis and intra-alveolar fibrosis which was often focal with an associated mild lymphoplasmacytic infiltrate, intra-alveolar oedema, macrophages, and some neutrophils. Ultrastructural studies showed electron lucency of type I pneumocytes, with breaks in the cytoplasmic membranes leaving a bare basement membrane. Degenerative change was also seen in endothelial cell cytoplasm along with lipofuscin deposition. While BCNU pulmonary fibrosis has been described up to 2 years after treatment, this complication so late after therapy, though rare, has important implications for the follow-up of patients receiving this drug.
    Citation
    Late BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma. 1991, 164 (1):31-6 J. Pathol.
    Journal
    The Journal of Pathology
    URI
    http://hdl.handle.net/10541/104535
    DOI
    10.1002/path.1711640106
    PubMed ID
    2056387
    Type
    Article
    Language
    en
    ISSN
    0022-3417
    ae974a485f413a2113503eed53cd6c53
    10.1002/path.1711640106
    Scopus Count
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