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    The effects of unequal sister chromatid exchange on length of arrays of repeated sequences.

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    Authors
    Fletcher, H L
    Rafferty, Joseph A
    Affiliation
    Division of Genetic Engineering, School of Biology and Biochemistry, Queens University of Belfast.
    Issue Date
    1993-10-21
    
    Metadata
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    Abstract
    Models of homogenization of repeated sequences by unequal sister chromatid exchange (USCE) assume that no significant changes in array length occur. The effects of successive USCEs on the lengths of arrays of repeated sequences has been examined mathematically and by simulation, assuming misalignment to be greater in longer arrays, a condition necessary for homogenization. The series of duplications and deletions gives a wide, asymmetric variation in copy number. Frequencies follow a binomial distribution, but if misalignment increases with array length, lengths become logarithmically distributed, most arrays being shorter than the original, counterbalanced by a few very long arrays. The median length, which is also the modal length, decreases exponentially or asymptotically. Given a proportional misalignment of a, the median (mode) decreases by a2/2 per unequal crossover. Since drift is a random transmission of available alleles in the population, it follows that fixation of common short arrays is much more probable than fixation of rare long arrays. This process will continue inexorably until each array is too short to undergo further unequal crossing over, and no more variation is generated. The number of unequal crossovers required by some published models of homogenization would almost certainly cause dramatic reduction in number, or complete loss, of repeats. Frequent unequal sister chromatid exchanges are not compatible with survival of arrays unless counteracted by an independent amplification mechanism or selection, so are unlikely to be important as a long-term homogenization mechanism in non-essential repeated sequences.
    Citation
    The effects of unequal sister chromatid exchange on length of arrays of repeated sequences. 1993, 164 (4):507-14 J. Theor. Biol.
    Journal
    Journal of Theoretical Biology
    URI
    http://hdl.handle.net/10541/104533
    DOI
    10.1006/jtbi.1993.1169
    PubMed ID
    8264247
    Type
    Article
    Language
    en
    ISSN
    0022-5193
    ae974a485f413a2113503eed53cd6c53
    10.1006/jtbi.1993.1169
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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