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    Stimulator of proliferation of spleen colony-forming cells in acute sterile inflammation.

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    Authors
    Milenković, P
    Ivanović, Z
    Lukić, M L
    Kataranovski, M
    Lord, Brian I
    Affiliation
    Institute for Medical Research, University of Beograd, Yugoslavia (Serbia).
    Issue Date
    1993-11
    
    Metadata
    Show full item record
    Abstract
    The presence and activity of a spleen colony-forming cell (CFU-S) proliferation stimulator was investigated in rat bone marrow after induction of sterile inflammation. Wistar rats were treated intraperitoneally with two 15 ml injections of 3.5% polyvinylpyrrolidone (PVP) at 18 h intervals, and the presence of CFU-S proliferation stimulator determined in bone marrow 6, 20 and 24 h after the first injection. The marrow of these mice was used to condition medium which was then fractionated using Amicon Diaflo ultrafiltration membranes. The 30-50 kDa fraction, taken from 20h post-PVP-bone marrow extract, was found to induce cycling of d8-CFU-S in normal mouse bone marrow. This activity was not related to the presence of interleukins-1, -2 or -6 like activities in the material tested. The results demonstrate the existence of CFU-S proliferation stimulator in the bone marrow of rats with sterile inflammation (i.e. in an in vivo tissue response to non-specific cell stimulation), similar to that originally described as a macrophage product in mouse bone marrow after treatment with a variety of cytotoxic agents.
    Citation
    Stimulator of proliferation of spleen colony-forming cells in acute sterile inflammation. 1993, 26 (6):503-10 Cell Prolif.
    Journal
    Cell Proliferation
    URI
    http://hdl.handle.net/10541/101873
    DOI
    10.1111/j.1365-2184.1993.tb00028.x
    PubMed ID
    9116117
    Type
    Article
    Language
    en
    ISSN
    0960-7722
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2184.1993.tb00028.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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